The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes

The Mouse Genomes Project was initiated in 2009 with the goal of using next-generation sequencing technologies to catalogue molecular variation in the common laboratory mouse strains, and a selected set of wild-derived inbred strains. The initial sequencing and survey of sequence variation in 17 inb...

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Published inMammalian genome Vol. 26; no. 9-10; pp. 403 - 412
Main Authors Adams, David J., Doran, Anthony G., Lilue, Jingtao, Keane, Thomas M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2015
Springer Nature B.V
Subjects
Animal Genetics and Genomics
Animals
Base Sequence
Biomedical and Life Sciences
Cell Biology
DNA Transposable Elements - genetics
Genome
Genomics
Human Genetics
Life Sciences
Mice
Mice, Inbred Strains - genetics
Polymorphism, Single Nucleotide - genetics
RNA Processing, Post-Transcriptional - genetics
Mouse Reference Genome
Laboratory Mouse Strain
Large Structural Variant
Variant Call Format
Sequence Ontology
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Summary:The Mouse Genomes Project was initiated in 2009 with the goal of using next-generation sequencing technologies to catalogue molecular variation in the common laboratory mouse strains, and a selected set of wild-derived inbred strains. The initial sequencing and survey of sequence variation in 17 inbred strains was completed in 2011 and included comprehensive catalogue of single nucleotide polymorphisms, short insertion/deletions, larger structural variants including their fine scale architecture and landscape of transposable element variation, and genomic sites subject to post-transcriptional alteration of RNA. From this beginning, the resource has expanded significantly to include 36 fully sequenced inbred laboratory mouse strains, a refined and updated data processing pipeline, and new variation querying and data visualisation tools which are available on the project’s website ( http://www.sanger.ac.uk/resources/mouse/genomes/ ). The focus of the project is now the completion of de novo assembled chromosome sequences and strain-specific gene structures for the core strains. We discuss how the assembled chromosomes will power comparative analysis, data access tools and future directions of mouse genetics.
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ISSN:0938-8990
1432-1777
DOI:10.1007/s00335-015-9579-6