Metal-catalyzed C-H functionalization involving isocyanides

Isocyanides have a broad range of applications in multicomponent reactions such as Passerini and Ugi processes. Recent advances in metal catalysis have tremendously increased the versatility of isocyanides in organic chemistry. Suitable metal catalysts could selectively activate various C-H bonds to...

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Bibliographic Details
Published inChemical Society reviews Vol. 46; no. 4; pp. 113 - 1123
Main Authors Song, Bingrui, Xu, Bin
Format Journal Article
LanguageEnglish
Published England 20.02.2017
Subjects
Activation
Catalysis
Chemical bonds
Construction equipment
Construction materials
Insertion
Organic chemistry
Strategy
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Summary:Isocyanides have a broad range of applications in multicomponent reactions such as Passerini and Ugi processes. Recent advances in metal catalysis have tremendously increased the versatility of isocyanides in organic chemistry. Suitable metal catalysts could selectively activate various C-H bonds to allow direct functionalization under mild conditions, which represents a chemical process with broad synthetic potential. The synergy from the combination of isocyanide insertion and C-H bond activation offers an efficient and powerful tool to establish complicated reactions and to construct useful substances, from which the high potential of such strategy has been convincingly demonstrated in drug discovery, organic synthesis, and materials science. The present review highlights the most recent advances of isocyanide chemistry in metal-catalyzed C-H bond functionalization. This review demonstrates the metal-catalyzed incorporation of isocyanides into C-H functionalization to establish complicated reactions utilizing synergistic effects.
Bibliography:Bingrui Song was born in 1982 in Weihui, Henan province, China. He received his Bachelor's degree (2004) and Master's degree (2009) under the supervision of Prof. Bin Xu from the Department of Chemistry at Shanghai University. In 2009, he moved to Germany to pursue his PhD studies under the supervision of Prof. Lukas J. Gooßen at Technical University of Kaiserslautern (2009-2013). His academic research focuses on the sustainable organic syntheses utilizing homogeneous and heterogeneous metal catalysts. In May 2013, he joined Clariant Chemicals as an R&D scientist, where he worked on sustainable and renewable surfactants and functional chemicals.
Bin Xu received his bachelor's degree from Shanghai University of Science and Technology in 1992. He conducted his PhD research with Professor Shengming Ma at Shanghai Institute of Organic Chemistry and completed his degree in 2000. After a two-year postdoctoral training at National Institutes of Health (NIH, MD, USA) as a Visiting Fellow (2000-2002, Mentor: Dr Kenneth A. Jacobson), he joined VivoQuest as a staff scientist (2002-2005). He began his independent academic career at Shanghai University in the end of 2005 as a Full Professor. His current research interests span the development of new methodology for nitrogen-containing heterocycles.
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ISSN:0306-0012
1460-4744
DOI:10.1039/c6cs00384b