Clinicopathological features of intraductal papillary mucinous neoplasm derived from ectopic pancreas: A systematic review

• Published in: Surgery open science Vol. 8; pp. 62 - 68
• Main Authors: Kimura, Jiro, Okabayashi, Takehiro, Sui, Kenta, Murokawa, Takahiro, Tabuchi, Motoyasu, Aida, Masaki, Iwata, Jun, Hata, Yasuhiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2022; Elsevier
• Subjects: Original
• ISSN: 2589-8450; 2589-8450
• DOI: 10.1016/j.sopen.2022.03.001

Clinicopathological characteristics of intraductal papillary mucinous neoplasm derived from the ectopic pancreas have not been elucidated owing to its rarity. MEDLINE databases from 1985 to 2021 were searched. Data regarding patient characteristics, diagnostic modalities, treatment, and prognosis were extracted from the identified articles. Comprehensive data on 13 patients (10 men and 3 women) with intraductal papillary mucinous neoplasm derived from ectopic pancreas were extracted. The median age was 69 years (range, 42–80 years). The tumors were located in the stomach in 6 patients, the duodenum in 1 patient, jejunum in 3 patients, ileum in 1 patient, and Meckel diverticulum in 2 patients. Histopathological examination revealed intraductal papillary mucinous neoplasm in 10 patients and intraductal papillary mucinous carcinoma in 3 patients. The median size of the tumor was not significantly different between the intraductal papillary mucinous carcinoma group and the intraductal papillary mucinous neoplasm group (P = .611). Accurate preoperative diagnosis and differential diagnosis between intraductal papillary mucinous neoplasm and intraductal papillary mucinous carcinoma remain difficult despite recent advances in imaging modalities. •The ectopic pancreas can be complicated with pancreatitis, pseudocyst formation, cyst formation, insulinoma, adenoma, and malignant transformation. Intraductal papillary mucinous neoplasm (IPMN) derived from the ectopic pancreas is rare and can undergo malignant transformation.•It is challenging to diagnose IPMN derived from ectopic pancreas preoperatively using the existing imaging modalities. Moreover, the clinicopathological characteristics of these tumors have not been elucidated.•We performed a review of case reports on IPMNs derived from the ectopic pancreas, including intraductal papillary mucinous carcinoma (IPMC) that was treated in our hospital, to determine the clinicopathological features of the tumors.•This is the first systematic review of the literature on IPMN derived from the ectopic pancreas. The review revealed that IPMN derived from the ectopic pancreas was diagnosed incidentally in most patients, and some patients were asymptomatic.•The existing imaging modalities may not accurately diagnose the condition preoperatively and differentiate between IPMN and IPMC. Risk factors for malignant transformation should be clarified through further research.