A comparative study between single-operator pancreatoscopy with intraductal lithotripsy and extracorporeal shock wave lithotripsy for the management of large main pancreatic duct stones

• Published in: Surgical endoscopy Vol. 36; no. 5; pp. 3217 - 3226
• Main Authors: Bick, Benjamin L., Patel, Feenalie, Easler, Jeffrey J., Tong, Yan, Watkins, James L., McHenry, Lee, Lehman, Glen, Fogel, Evan L., Gromski, Mark A., Sherman, Stuart
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2022; Springer Nature B.V
• Subjects: Abdomen; Abdominal Surgery; Calcification; Calculi - therapy; Cholangiopancreatography, Endoscopic Retrograde - methods; Endoscopy; Gallstones; Gastroenterology; Gynecology; Hepatology; Humans; Lithotripsy; Lithotripsy - methods; Medicine; Medicine & Public Health; Pancreas; Pancreatic Diseases - etiology; Pancreatic Diseases - therapy; Pancreatic Ducts; Pancreatitis; Patients; Proctology; Retrospective Studies; Success; Surgery; Treatment Outcome; Visualization; Pancreatic duct stones; Endoscopic retrograde cholangiopancreatography; Electrohydraulic shock wave lithotripsy; Extracorporeal shock wave lithotripsy; Chronic pancreatitis
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-021-08631-7

Background and aims Endoscopic management of large main pancreatic ductal (MPD) stones often require treatment with lithotripsy. Extracorporeal shock wave lithotripsy (ESWL) has been the mainstay therapy, and single-operator pancreatoscopy with intraductal (intracorporeal) lithotripsy (SOPIL) is an emerging technique. However, no comparative studies between these techniques exist. We therefore aimed to compare ESWL to SOPIL for the treatment of large MPD stones. Methods This is a retrospective cohort study comparing patients who were treated with ESWL or SOPIL from September 2013 to September 2019 at a single tertiary center. Logistic regression was performed to identify factors associated with technical success and efficient stone clearance (≤ 2 procedures to clear stones). Results There were 240 patients who were treated with ESWL and 18 treated with SOPIL. The overall technical success rate of stone clearance was 224/258 (86.8%), which was similar between the ESWL and SOPIL groups (86.7% vs 88.9%, p  = 1.000). A SOPIL approach required fewer total procedures (1.6 ± 0.6 vs 3.1 ± 1.5, p  < 0.001) and less aggregate procedure time (101.6 ± 68.2 vs 191.8 ± 111.6 min, p  = 0.001). Adverse event rates were similar between the groups (6.3% vs 5.6%, p  = 1.000). The use of SOPIL was independently associated with greater efficiency compared to ESWL (OR 5.241 [1.348–20.369], p  = 0.017). Stone size > 10 mm was associated with less efficient stone clearance (OR 0.484 [0.256–0.912], p  = 0.025). Conclusion Both ESWL and SOPIL are safe and effective endoscopic adjunct modalities for treating large pancreatic duct stones. SOPIL is an emerging alternative to ESWL that is potentially more efficient for lithotripsy and MPD stone clearance.