Neural effects of continuous theta-burst stimulation in macaque parietal neurons

Theta-burst transcranial magnetic stimulation (TBS) has become a standard non-invasive technique to induce offline changes in cortical excitability in human volunteers. Yet, TBS suffers from a high variability across subjects. A better knowledge about how TBS affects neural activity in vivo could un...

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Bibliographic Details
Published ineLife Vol. 11
Main Authors Romero, Maria C, Merken, Lara, Janssen, Peter, Davare, Marco
Format Journal Article
LanguageEnglish
Published England eLife Sciences Publications Ltd 13.09.2022
eLife Sciences Publications, Ltd
Subjects
Achievement tests
Animals
Cortical Excitability
electrophysiology
Excitability
Gastropoda
Healthy Volunteers
Humans
Light
Macaca mulatta
Magnetic fields
Magnetic resonance imaging
Neurons
Neuroscience
parietal
Transcranial magnetic stimulation
Transcranial Magnetic Stimulation - methods
rhesus macaque
transcranial magnetic stimulation
electrophysiology
parietal
neuroscience
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Summary:Theta-burst transcranial magnetic stimulation (TBS) has become a standard non-invasive technique to induce offline changes in cortical excitability in human volunteers. Yet, TBS suffers from a high variability across subjects. A better knowledge about how TBS affects neural activity in vivo could uncover its mechanisms of action and ultimately allow its mainstream use in basic science and clinical applications. To address this issue, we applied continuous TBS (cTBS, 300 pulses) in awake behaving rhesus monkeys and quantified its after-effects on neuronal activity. Overall, we observed a pronounced, long-lasting, and highly reproducible reduction in neuronal excitability after cTBS in individual parietal neurons, with some neurons also exhibiting periods of hyperexcitability during the recovery phase. These results provide the first experimental evidence of the effects of cTBS on single neurons in awake behaving monkeys, shedding new light on the reasons underlying cTBS variability.
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These authors contributed equally to this work.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.65536