Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null ( Cnr1−/− ) mice

• Published in: Medical engineering & physics Vol. 38; no. 10; pp. 1044 - 1054
• Main Authors: Khalid, Aysha B, Goodyear, Simon R, Ross, Ruth A, Aspden, Richard M
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2016
• Subjects: Animals; Biomechanical Phenomena; Bone; Cancellous Bone - diagnostic imaging; Cancellous Bone - metabolism; Cannabinoid receptor 1; Cortical bone; Cortical Bone - diagnostic imaging; Cortical Bone - metabolism; Female; Femur - diagnostic imaging; Femur - metabolism; Gene Knockout Techniques; Male; Material properties; Mechanical Phenomena; Mechanical properties; Mice; Mice, Inbred C57BL; Radiology; Receptor, Cannabinoid, CB1 - deficiency; Receptor, Cannabinoid, CB1 - genetics; Tibia - diagnostic imaging; Tibia - metabolism; Trabecular bone; X-Ray Microtomography; Mechanical properties; Trabecular bone; Cannabinoid receptor 1; Bone; Cortical bone; Material properties
• ISSN: 1350-4533; 1873-4030
• DOI: 10.1016/j.medengphy.2016.06.024

Highlights • Cannabinoid receptor 1 in C57BL/6 mice regulates trabecular and cortical bone. • Deleting Cnr1 improves trabecular bone quality in females. • Cnr1−/− adversely affects cortical bone strength and stiffness in both sexes. • Cnr1−/− results in slower bone growth and smaller bones.