Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus

• Published in: Nanomaterials (Basel, Switzerland) Vol. 7; no. 11; p. 365
• Main Authors: Lee, Joomin, Choi, Kyong-Hoon, Min, Jeeeun, Kim, Ho-Joong, Jee, Jun-Pil, Park, Bong Joo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.11.2017; MDPI
• Subjects: Antibacterial activity; antibiotic resistance; Antioxidants; antioxidative activity; Bacteria; Bactericidal activity; Chemical bonds; Drug resistance; E coli; Gallic acid; Gram-negative bacteria; Gram-positive bacteria; Methicillin; methicillin-resistant Staphylococcus aureus; Nanoparticles; Selectivity; Staphylococcus aureus; Staphylococcus infections; Strains (organisms); Sulfonic acid; Zinc oxide; ZnO@GA; antibacterial activity; ZnO@GA; methicillin-resistant Staphylococcus aureus; antioxidative activity; antibiotic resistance; gallic acid
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano7110365

In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. ZnO@GA nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant activity and high affinity for the bacterial cell membrane. Antioxidative activities at various concentrations were evaluated using a 2,2'-azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method. Antibacterial activities were evaluated against Gram-positive bacteria ( ), including several strains of methicillin-resistant (MRSA), and Gram-negative bacteria ( ). The functionalized ZnO@GA nanoparticles showed good antioxidative activity (69.71%), and the bactericidal activity of these nanoparticles was also increased compared to that of non-functionalized ZnO nanoparticles, with particularly effective inhibition and high selectivity for MRSA strains. The results indicate that multifunctional ZnO nanoparticles conjugated to GA molecules via a simple surface modification process displaying both antioxidant and antibacterial activity, suggesting a possibility to use it as an antibacterial agent for removing MRSA.