Cubic Magnetically Guided Nanoaggregates for Inhalable Drug Delivery: In Vitro Magnetic Aerosol Deposition Study

The present work describes the in vitro aerosol deposition and enhanced deaggregation behavior of superparamagnetic iron oxide nanoaggregates (SPIONs). SPIONs were surface-coated with amine functionalized polyrotaxane and were proposed as a carrier for inhalation dry powders. Polyrotaxane is primari...

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Bibliographic Details
Published inAAPS PharmSciTech Vol. 14; no. 3; pp. 977 - 993
Main Authors Ragab, Doaa Mohamed, Rohani, Sohrab
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.09.2013
Subjects
Administration, Inhalation
Aerosols
Aerosols - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Delivery Systems
In Vitro Techniques
Magnetics
Microscopy, Electron, Scanning
Nanoparticles
Pharmacology/Toxicology
Pharmacy
Research Article
saturation magnetization
aerosol deposition
magnetic next generation impinger
polyrotaxane
magnetic nanoaggregates
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Summary:The present work describes the in vitro aerosol deposition and enhanced deaggregation behavior of superparamagnetic iron oxide nanoaggregates (SPIONs). SPIONs were surface-coated with amine functionalized polyrotaxane and were proposed as a carrier for inhalation dry powders. Polyrotaxane is primarily composed of beta cyclodextrin rings which are spontaneously threaded on the block copolymer, poly(propylene glycol) bis(2-aminopropylether). Variable concentrations of surface coating polymers showed controlled manipulation of the crystal size and morphology. Magnetic nanoaggregates fabricated with low concentration of polyrotaxane showed cubic crystal morphology. However, these nanoaggregates exhibited rhombic dodecahedron crystal structure upon increasing the coating polymer concentration. In comparison to the spherical uncoated magnetic nanoparticles, cubic phase magnetic nanoaggregates demonstrated an enhanced in vitro aerosol deposition using magnetic field alignment. This enhancement can be accomplished at low inhalation flow rates (15 and 30 L/min). However, transformation to the cubic crystal structure was observed to be associated with a reduction in the powder geometric standard deviation. Using a mathematical modeling approach, we noted significant enhancement in the deaggregation behavior of inhalation dry powders; that can be achieved with small amounts of magnetic nanoaggregates. Aggregates of cubic nanoparticles showed promise for targeted pulmonary deposition of anticancer drugs. Figure Cubic magnetic nanoaggregates for systemic pulmonary drug delivery
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ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-013-9980-y