Distinct neural mechanisms underlie subjective and objective recollection and guide memory-based decision making

• Published in: eLife Vol. 10
• Main Authors: Fandakova, Yana, Johnson, Elliott G, Ghetti, Simona
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 09.03.2021; eLife Sciences Publications, Ltd
• Subjects: Accuracy; Adult; Cortex (parietal); Decision making; Decision Making - physiology; Female; Gyrus Cinguli - physiology; Humans; insula; Male; memory; Mental Recall - physiology; Metacognition; metamemory; Neuroscience; Older people; parietal; Parietal lobe; Parietal Lobe - physiology; prefrontal; Reinforcement; Young Adult; memory; prefrontal; neuroscience; decision making; metamemory; insula; human; parietal
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/eLife.62520

Accurate memories are often associated with vivid experiences of recollection. However, the neural mechanisms underlying subjective recollection and their unique role in decision making beyond accuracy have received limited attention. We dissociated subjective recollection from accuracy during a forced-choice task. Distractors corresponded either to non-studied exemplars of the targets (A-A' condition) or to non-studied exemplars of different studied items (A-B' condition). The A-A' condition resulted in higher accuracy and greater activation in the superior parietal lobe, whereas the A-B' condition resulted in higher subjective recollection and greater activation in the precuneus and retrosplenial regions, indicating a dissociation between objective and subjective memory. Activation in insular, cingulate, and lateral prefrontal regions was also associated with subjective recollection; however, during a subsequent decision phase, activation in these same regions was greater for discarded than for selected responses in anticipation of a social reward, underscoring their role in evaluating memory evidence flexibly based on current goals.