Pituitary T1 signal intensity at magnetic resonance imaging is reduced in patients with obesity: results from the CHIASM study

• Published in: International Journal of Obesity Vol. 47; no. 10; pp. 948 - 955
• Main Authors: Puliani, Giulia, Sbardella, Emilia, Cozzolino, Alessia, Sada, Valentina, Tozzi, Rossella, Andreoli, Chiara, Fiorelli, Marco, Di Biasi, Claudio, Corallino, Diletta, Balla, Andrea, Paganini, Alessandro M., Venneri, Mary Anna, Lenzi, Andrea, Lubrano, Carla, Isidori, Andrea M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2023; Nature Publishing Group
• Subjects: 59; 59/57; 692/308/2779/109; 692/699/2743/393; Body weight; Correlation; Dual energy X-ray absorptiometry; Epidemiology; Evaluation; Fibrinogen; Growth factors; Health Promotion and Disease Prevention; Insulin-like growth factor I; Internal Medicine; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Metabolic Diseases; Obesity; Pituitary; Pituitary hormones; Public Health; Subgroups
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/s41366-023-01338-w

Background Despite obesity being well known to be associated with several pituitary hormone imbalances, pituitary appearance in magnetic resonance imaging (MRI) in patients with obesity is understudied. Objective To evaluate the pituitary volume and signal intensity at MRI in patients with obesity. Methods This is a prospective study performed in an endocrine Italian referral center (ClinicalTrial.gov Identifier: NCT03458533). Sixty-nine patients with obesity (BMI > 30 kg/m 2 ) and twenty-five subjects without obesity were enrolled. Thirty-three patients with obesity were re-evaluated after 3 years of diet and lifestyle changes, of whom 17 (51.5%) achieved a > 5% loss of their initial body weight, whereas the remaining 16 (48.5%) had maintained or gained weight. Evaluations included metabolic and hormone assessments, DEXA scan, and pituitary MRI. Pituitary signal intensity was quantified by measuring the pixel density using ImageJ software. Results At baseline, no difference in pituitary volume was observed between the obese and non-obese cohorts. At the 3-year follow-up, pituitary volume was significantly reduced ( p  = 0.011) only in participants with stable-increased body weight. Furthermore, a significant difference was noted in the mean pituitary intensity of T1-weighted plain and contrast-enhanced sequences between the obese and non-obese cohorts at baseline ( p  = 0.006; p  = 0.002), and a significant decrease in signal intensity was observed in the subgroup of participants who had not lost weight ( p  = 0.012; p  = 0.017). Insulin-like growth factor-1 levels, following correction for BMI, were correlated with pituitary volume ( p  = 0.001) and intensity ( p  = 0.049), whereas morning cortisol levels were correlated with pituitary intensity ( p  = 0.007). The T1-weighted pituitary intensity was negatively correlated with truncal fat ( p  = 0.006) and fibrinogen ( p  = 0.018). Conclusions The CHIASM study describes a quantitative reduction in pituitary intensity in T1-weighted sequences in patients with obesity. These alterations could be explained by changes in the pituitary stromal tissue, correlated with low-grade inflammation.