The vertebrate muscle superlattice: discovery, consequences, and link to geometric frustration

Early x-ray diffraction studies of muscle revealed spacings larger than the basic thick filament lattice spacing and led to a number of speculations on the mutual rotations of the filaments in the myosin lattice. The nature of the arrangements of the filaments was resolved by John Squire and Pradeep...

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Bibliographic Details
Published inJournal of muscle research and cell motility Vol. 44; no. 3; pp. 153 - 163
Main Authors Millane, Rick P., Luther, Pradeep K.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.09.2023
Springer Nature B.V
Subjects
Animal Anatomy
Biomedical and Life Sciences
Biomedicine
Cell Biology
Electron microscopy
Filaments
Histology
Image processing
Lattice theory
Life Sciences
Mechanical properties
Microscopy
Morphology
Motility
Musculoskeletal system
Myosin
Proteomics
Review Paper
X-ray diffraction
Myosin superlattice
Ising model
Vertebrate muscle
Frustration
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Summary:Early x-ray diffraction studies of muscle revealed spacings larger than the basic thick filament lattice spacing and led to a number of speculations on the mutual rotations of the filaments in the myosin lattice. The nature of the arrangements of the filaments was resolved by John Squire and Pradeep Luther using careful electron microscopy and image analysis. The intriguing disorder in the rotations, that they termed the myosin superlattice, remained a curiosity, until work with Rick Millane and colleagues showed a connection to “geometric frustration,” a well-known phenomenon in statistical and condensed matter physics. In this review, we describe how this connection gives a satisfying physical basis for the myosin superlattice, and how recent work has shown relationships to muscle mechanical behaviour.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0142-4319
1573-2657
DOI:10.1007/s10974-023-09642-8