Catecholamines, α-, and β-Adrenoceptors Are Not Responsible for Activation of Duodenum Motility Induced by Sympathetic Nerve Stimulation

• Published in: Bulletin of experimental biology and medicine Vol. 152; no. 1; pp. 5 - 8
• Main Authors: Sveshnikov, D. S., Smirnov, V. M., Myasnikov, I. L., Mongush, M. I., Yurasova, I. A.
• Format: Journal Article
• Language: English; Russian
• Published: Boston Springer US 01.11.2011; Springer
• Subjects: Adrenergic alpha-Antagonists - pharmacology; Adrenergic beta-Antagonists - pharmacology; Adrenergic Fibers - metabolism; Adrenergic Fibers - physiology; Animals; Biomedical and Life Sciences; Biomedicine; Bretylium Tosylate - pharmacology; Catecholamines; Cell Biology; Data processing; Dogs; Duodenum; Duodenum - innervation; Duodenum - metabolism; Duodenum - physiology; Electric Stimulation; Female; Gastrointestinal Motility; Gastrointestinal system; Internal Medicine; Laboratory Medicine; Male; Motility; Pathology; phentolamine; Phentolamine - pharmacology; Propranolol; Propranolol - pharmacology; Propranolol hydrochloride; Receptors, Adrenergic, alpha - metabolism; Receptors, Adrenergic, beta - metabolism; sympathetic nerves; catecholamines; neural control; duodenum; α- and β-adrenoceptors
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-011-1438-1

Stimulation of sympathetic nerve in anesthetized dogs not treated with adrenergic blockers more frequently exerted stimulating rather than inhibitory effect on duodenal motility. Blockade of α- and β-adrenoceptors with phentolamine and propranolol, respectively, did not prevent the excitatory action of the sympathetic nerve stimulation, but even potentiated this effect. The data showed that catecholamines as well as α- and β-adrenoceptors are not involved in the excitatory effect of sympathetic origin.