A vertebral skeletal stem cell lineage driving metastasis

• Published in: Nature (London) Vol. 621; no. 7979; pp. 602 - 609
• Main Authors: Sun, Jun, Hu, Lingling, Bok, Seoyeon, Yallowitz, Alisha R., Cung, Michelle, McCormick, Jason, Zheng, Ling J., Debnath, Shawon, Niu, Yuzhe, Tan, Adrian Y., Lalani, Sarfaraz, Morse, Kyle W., Shinn, Daniel, Pajak, Anthony, Hammad, Mohammed, Suhardi, Vincentius Jeremy, Li, Zan, Li, Na, Wang, Lijun, Zou, Weiguo, Mittal, Vivek, Bostrom, Mathias P. G., Xu, Ren, Iyer, Sravisht, Greenblatt, Matthew B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.09.2023; Nature Publishing Group
• Subjects: 13/100; 14/1; 631/532; 631/67/322/803; Adipocytes; Biomarkers; Bone growth; Bones; Breast cancer; Breast Neoplasms - pathology; Cartilage; Cell Differentiation; Cell Lineage; Cell Self Renewal; Cell surface; Differentiation; Humanities and Social Sciences; Humans; Labeling; Long bone; Metastases; Metastasis; multidisciplinary; Neoplasm Metastasis - pathology; Osteoblasts - cytology; Osteoblasts - pathology; Osteogenesis; Physiology; Science; Science (multidisciplinary); Solid tumors; Spine - cytology; Spine - pathology; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Stem Cells - pathology; Surface markers; Transcription factors; Tropism; Vertebrae

Vertebral bone is subject to a distinct set of disease processes from long bones, including a much higher rate of solid tumour metastases 1 – 4 . The basis for this distinct biology of vertebral bone has so far remained unknown. Here we identify a vertebral skeletal stem cell (vSSC) that co-expresse...