Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

Bone is remodeled continuously during adulthood through the resorption of old bone by osteoclasts and the subsequent formation of new bone by osteoblasts. These two closely coupled events are responsible for renewing the skeleton while maintaining its anatomical and structural integrity. Under norma...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 332; no. 5; pp. 305 - 311
Main Authors Manolagas, Stavros C, Jilka, Robert L
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 02.02.1995
Subjects
Animals
Biological and medical sciences
Bone marrow
Bone Marrow - physiopathology
Bone Remodeling
Colonies & territories
Cytokines
Cytokines - physiology
Diseases of the osteoarticular system
Female
Humans
Medical sciences
Osteoblasts - physiology
Osteoclasts - physiology
Osteoporosis - physiopathology
Osteoporosis. Osteomalacia. Paget disease
Transplants & implants
Human
Interleukin 6
Osteoporosis
Pathophysiology
Cytokine
Diseases of the osteoarticular system
Bone marrow
Exploration
Osteoclast
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Summary:Bone is remodeled continuously during adulthood through the resorption of old bone by osteoclasts and the subsequent formation of new bone by osteoblasts. These two closely coupled events are responsible for renewing the skeleton while maintaining its anatomical and structural integrity. Under normal conditions, bone remodeling proceeds in cycles in which osteoclasts adhere to bone and subsequently remove it by acidification and proteolytic digestion. Shortly after the osteoclasts have left the resorption site, osteoblasts invade the area and begin the process of forming new bone by secreting osteoid (a matrix of collagen and other proteins), which is eventually mineralized. After . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199502023320506