Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer

• Published in: Familial cancer Vol. 23; no. 3; pp. 323 - 339
• Main Authors: Bogdanski, Aleksander M., van Hooft, Jeanin E., Boekestijn, Bas, Bonsing, Bert A., Wasser, Martin N. J. M., Klatte, Derk C. F., van Leerdam, Monique E.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.08.2024; Springer Nature B.V
• Subjects: Adenocarcinoma; Biomedical and Life Sciences; Biomedicine; Cancer Research; Epidemiology; Family medical history; Genes; Human Genetics; Medical prognosis; Medical screening; Pancreatic cancer; Pancreatitis; Prognosis; Review; Surveillance; Pancreatic cancer surveillance; High-risk individuals; Pancreatic ductal adenocarcinoma; Early detection
• ISSN: 1389-9600; 1573-7292; 1573-7292
• DOI: 10.1007/s10689-024-00368-1

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths and is associated with a poor prognosis. The majority of these cancers are detected at a late stage, contributing to the bad prognosis. This underscores the need for novel, enhanced early detection strategies to improve the outcomes. While population-based screening is not recommended due to the relatively low incidence of PDAC, surveillance is recommended for individuals at high risk for PDAC due to their increased incidence of the disease. However, the outcomes of pancreatic cancer surveillance in high-risk individuals are not sorted out yet. In this review, we will address the identification of individuals at high risk for PDAC, discuss the objectives and targets of surveillance, outline how surveillance programs are organized, summarize the outcomes of high-risk individuals undergoing pancreatic cancer surveillance, and conclude with a future perspective on pancreatic cancer surveillance and novel developments.