Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?

Exposure to airborne substances such as gases, vapours, and particles remains a relevant health risk in many workplaces. A current topic and cause for discussion is the investigation of the health effects of particles containing zinc oxide (ZnO). Among other data, those collected from our study on h...

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Bibliographic Details
Published inArchives of toxicology Vol. 97; no. 10; pp. 2813 - 2818
Main Authors Monsé, Christian, Merget, Rolf, Bünger, Jürgen, Pallapies, Dirk, Brüning, Thomas
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2023
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Environmental Health
Exposure limits
Health risks
Humans
Inflammation
Occupational exposure
Occupational Exposure - adverse effects
Occupational Exposure - analysis
Occupational health
Occupational Medicine/Industrial Medicine
Pharmacology/Toxicology
Regulatory agencies
Research facilities
Short Communication
Working conditions
Workplace
Workplaces
Zinc
Zinc oxide
Zinc Oxide - toxicity
Zinc oxides
Zinc oxide
Occupational exposure limit
Particles
Human inhalation studies
Systemic inflammatory parameter
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Summary:Exposure to airborne substances such as gases, vapours, and particles remains a relevant health risk in many workplaces. A current topic and cause for discussion is the investigation of the health effects of particles containing zinc oxide (ZnO). Among other data, those collected from our study on human exposure data of ZnO in 2018 prompted the National Research Centre for the Working Environment 2021 to formulate a new, sharply lowered proposed occupational exposure limit (OEL) for zinc in workplaces. Since the publication of the Danish report, further studies have been conducted with ZnO. In the following text, all arguments for deriving this new limit value for zinc from the report are discussed, extended with the more recent data since 2018. It should be noted that especially the application of time extrapolation factors needs further discussion and harmonization between regulatory authorities. From our point of view, the data situation can justify a higher OEL for zinc than that proposed by the Danish National Research Centre for the Working Environment.
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ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-023-03567-4