Metabolomic Profiles on Antiblastic Cardiotoxicity: New Perspectives for Early Diagnosis and Cardioprotection

Antiblastic drugs-induced cardiomyopathy remains a relevant cause of morbidity and mortality, during and after chemotherapy, despite the progression in protective therapy against cardiovascular diseases and myocardial function. In the last few decades, many groups of researchers have focused their a...

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Published inJournal of clinical medicine Vol. 11; no. 22; p. 6745
Main Authors Fazzini, Luca, Caggiari, Ludovica, Deidda, Martino, Onnis, Carlotta, Saba, Luca, Mercuro, Giuseppe, Cadeddu Dessalvi, Christian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 15.11.2022
MDPI
Subjects
Amino acids
Apoptosis
Biomarkers
Breast cancer
cadiotoxicity
cardioprotection
Cardiotoxicity
Chromatography
Clinical medicine
Enzymes
Heart failure
Histopathology
Magnetic resonance imaging
Mass spectrometry
Metabolism
Metabolites
metabolomics
NMR
Nuclear magnetic resonance
Review
Rodents
Scientific imaging
cardioprotection
heart failure
metabolomics
cadiotoxicity
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Summary:Antiblastic drugs-induced cardiomyopathy remains a relevant cause of morbidity and mortality, during and after chemotherapy, despite the progression in protective therapy against cardiovascular diseases and myocardial function. In the last few decades, many groups of researchers have focused their attention on studying the metabolic profile, first in animals, and, subsequently, in humans, looking for profiles which could be able to predict drug-induced cardiotoxicity and cardiovascular damage. In clinical practice, patients identified as being at risk of developing cardiotoxicity undergo a close follow-up and more tailored therapies. Injury to the heart can be a consequence of both new targeted therapies, such as tyrosine kinase inhibitors, and conventional chemotherapeutic agents, such as anthracyclines. This review aims to describe all of the studies carried on this topic of growing interest.
Bibliography:These authors share the first authorship.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11226745