Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 21; no. 7; pp. 848 - 854
• Main Authors: Collene, Angela L., Hertzler, Steven R., Williams, Jennifer A., Wolf, Bryan W.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2005; Elsevier; Elsevier Limited
• Subjects: Adult; alpha-Glucosidases - metabolism; Amino acids; Analysis of Variance; Area Under Curve; Beverages; Biological and medical sciences; Blood Glucose - drug effects; Blood Glucose - metabolism; Breath Tests; Celastraceae - chemistry; Cross-Over Studies; Diabetes; Double-Blind Method; Excretion; Feeding. Feeding behavior; Female; Flatulence - epidemiology; Functional foods & nutraceuticals; Fundamental and applied biological sciences. Psychology; Glucose; Glycemia; Glycoside Hydrolase Inhibitors; Humans; Hydrogen; Hyperglycemia; Insulin; Insulin - blood; Leucine - administration & dosage; Leucine - pharmacokinetics; Male; Meals; Phenylalanine - administration & dosage; Phenylalanine - pharmacokinetics; Plant Extracts - pharmacokinetics; Plant Extracts - pharmacology; Postprandial Period; Proteins; Salacia oblonga; Studies; Vertebrates: anatomy and physiology, studies on body, several organs or systems; α glucosidase inhibitor; Amino acids; α glucosidase inhibitor; Salacia oblonga; Glycemia; Human; Nutrition; Hydrogen; Postprandial; a glucosidase inhibitor; Extract; Vertebrata; Mammalia; Aminoacid; Adult
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2004.11.018

This study evaluated the postprandial glycemic, insulinemic, and breath hydrogen responses to a liquid nutritional product containing Salacia oblonga extract, an herbal α-glucosidase inhibitor, and two insulinogenic amino acids. In a randomized, double-masked, crossover design, 43 healthy subjects were fed the following meals on separate days after overnight fasting: control (C; 480 mL of a study beverage containing 82 g of carbohydrate, 20 g of protein, and 14 g of fat), control plus 3.5 g each of phenylalanine and leucine (AA), control plus 1000 mg of S. oblonga extract (S), and control plus S and AA (SAA). Postprandially, fingerstick capillary plasma glucose and venous serum insulin levels were measured for 180 min, and breath hydrogen excretion was measured for 480 min. The baseline-adjusted peak glucose response was not different across meals. However, changes in plasma glucose areas under the curve (0 to 120 min and 0 to 180 min, respectively) compared with C were −9% and −11% for AA ( P > 0.05 each), −27% and −24% for S ( P = 0.035 and 0.137), and −27% and −29% for SAA ( P < 0.05 each). Changes in insulin areas under the curve were +5% and +5% for AA ( P > 0.05 each), −35% and −36% for S ( P < 0.001 each), and −6% and −7% for SAA ( P > 0.05 each). Breath hydrogen excretion was 60% greater ( P < 0.001) in the S-containing meals than in the C- and AA-containing meals and was associated with mild flatulence. Salacia oblonga extract is a promising nutraceutical ingredient that decreased glycemia in this study. Supplementation with amino acids had no significant additional effect on glycemia.