Spectral oscillations of RR intervals in sleep apnoea/hypopnoea syndrome patients

• Published in: The European respiratory journal Vol. 22; no. 6; pp. 943 - 950
• Main Authors: Dingli, K, Assimakopoulos, T, Wraith, P.K, Fietze, I, Witt, C, Douglas, N.J
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.12.2003; Maney
• Subjects: Adult; Autonomic Nervous System Diseases - complications; Autonomic Nervous System Diseases - physiopathology; Biological and medical sciences; Cardiovascular Diseases - complications; Cardiovascular Diseases - physiopathology; Chronic obstructive pulmonary disease, asthma; Heart Rate - physiology; Humans; Medical sciences; Middle Aged; Pneumology; Polysomnography - methods; Sleep Apnea Syndromes - complications; Sleep Apnea Syndromes - physiopathology; Electrocapillarity; Human; Heart rate; Apnea; Lung function; Sleep; Pathophysiology; Respiratory disease; Sleep disorder; Electrocardiography; Exploration; Cardiovascular disease heart rate variability sleep apnoea
• ISSN: 0903-1936; 1399-3003
• DOI: 10.1183/09031936.03.00098002

A recent study has shown that daytime heart rate variability is reduced in obstructive sleep apnoea/hypopnoea syndrome (OSAHS) patients. In the present study, the hypothesis was that sympathovagal balance around apnoeas/hypopnoeas and nocturnal autonomic activity are altered in OSAHS patients. Frequency- and time-domain analyses of RR intervals were performed to monitor sympathovagal activity noninvasively. Fourteen untreated OSAHS patients and seven healthy subjects underwent overnight polysomnography. Low (LF) and total (TF) frequency power increased 2 min around the end of apnoeas/hypopnoeas (LF 229+/-38 ms2 TF 345+/-45 ms2) compared with undisturbed sleep (LF 106+/-18 ms2, TF 203+/-23 ms2). The increase in high frequency (HF) power was not significant. LF increase was proportionally higher than the HF increase (normalised LF (LFn) 67+/-1 units, normalised HF (HFn) 33+/-1 units) compared with undisturbed sleep (LFn 52+/-2 units, HFn 48+/-2 units). RR duration did not change around apnoeas/hypopnoeas (RR 904+/-28 ms). The LF and TF power increase was greater around arousal-inducing (LF 260+/-45 ms2 TF 390+/-65 ms2) compared with self-terminating (LF 161+/-31 ms2, TF 249+/-40 ms2) apnoeas/hypopnoeas; the LF and LFn increases were significant in both groups compared with undisturbed sleep and HF power differences were nonsignificant. RR intervals were longer around self-terminating apnoeas/hypopnoeas (RR 914+/-29 ms); the differences were not significant compared with undisturbed sleep. RR interval spectral power was not influenced by the event type. RR duration decreased (912+/-28 ms) and LF, HF and TF power increased (LF 111+/-16 ms2 , HF 62+/-6 ms , TF 173+/-21 ms2) across patients, compared with healthy controls (RR 1138+/-91 ms, LF 57+/-3 ms2, HF 35+/-3 ms2, TF 91+/-6 ms2). LFn and HFn did not change significantly. Sympathetic activity increases around apnoeas/hypopnoeas. The recurrent nocturnal fluctuations of sympathovagal balance and the overall increase of nocturnal autonomic activity may be of importance in the development of cardiovascular disease in sleep apnoea patients.