Translational relevance of forward genetic screens in animal models for the study of psychiatric disease
Psychiatric disorders represent a significant burden in our societies. Despite the convincing evidence pointing at gene and gene-environment interaction contributions, the role of genetics in the etiology of psychiatric disease is still poorly understood. Forward genetic screens in animal models hav...
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Published in | Neuroscience and biobehavioral reviews Vol. 135; p. 104559 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Ltd
01.04.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Psychiatric disorders represent a significant burden in our societies. Despite the convincing evidence pointing at gene and gene-environment interaction contributions, the role of genetics in the etiology of psychiatric disease is still poorly understood. Forward genetic screens in animal models have helped elucidate causal links. Here we discuss the application of mutagenesis-based forward genetic approaches in common animal model species: two invertebrates, nematodes (Caenorhabditis elegans) and fruit flies (Drosophila sp.); and two vertebrates, zebrafish (Danio rerio) and mice (Mus musculus), in relation to psychiatric disease. We also discuss the use of large scale genomic studies in human populations. Despite the advances using data from human populations, animal models coupled with next-generation sequencing strategies are still needed. Although with its own limitations, zebrafish possess characteristics that make them especially well-suited to forward genetic studies exploring the etiology of psychiatric disorders.
•Assays of core component behaviors associated with human psychiatric disease are established.•Behavioral screens in animal models predict loci affecting human behavior.•Next generation sequencing facilitates identification of candidate mutations.•Combining human and animal studies reveals the biology of human psychiatric disease. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Indicates joint first authorship |
ISSN: | 0149-7634 1873-7528 1873-7528 |
DOI: | 10.1016/j.neubiorev.2022.104559 |