Success Predictors of Endoscopic Sleeve Gastroplasty

• Published in: Obesity surgery Vol. 34; no. 5; pp. 1496 - 1504
• Main Authors: Matteo, Maria Valeria, Bove, Vincenzo, Ciasca, Gabriele, Carlino, Giorgio, Di Santo, Riccardo, Vinti, Laila, Polidori, Giulia, Pontecorvi, Valerio, Papi, Massimiliano, Spada, Cristiano, Boškoski, Ivo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2024; Springer Nature B.V
• Subjects: Body mass index; Diabetes; Endoscopy; Ethics; Females; Gastrointestinal surgery; Lifestyles; Males; Medicine; Medicine & Public Health; Metabolism; Multidisciplinary teams; Obesity; Original Contributions; Postoperative period; Quality of life; Success; Surgery; Sutures; Trends; Weight control; ESG; Obesity; Endoscopic sleeve gastroplasty; Predictors
• ISSN: 0960-8923; 1708-0428; 1708-0428
• DOI: 10.1007/s11695-024-07109-4

Objective Endoscopic sleeve gastroplasty (ESG) is a minimally invasive procedure that proved to be safe and effective in obesity treatment. However, not all subjects respond to treatment in the same way, and, with a view to personalized care, it is essential to identify predictors of success or failure. Methods A retrospective 2-year followed-up cohort of ESG subjects was analyzed to investigate the presence of any baseline or early indicators of long-term optimal or suboptimal ESG outcomes. Results A total of 315 subjects (73% women) were included, with 73% of patients exhibiting an Excess weight loss percentage (%EWL) >25% at the 24 months. Neither demographic parameters (age and sex), smoking habits, and menopause in women nor the presence of comorbidities proved potential predictive value. Interestingly, the %EWL at 1 month after ESG was the strongest predictor of 24-month therapeutic success. Subsequently, we estimated an “early threshold for success” for 1 month-%EWL by employing Youden’s index method. Conclusions ESG is a safe and effective bariatric treatment that can be offered to a wide range of subjects. Early weight loss seems to impact long-term ESG results significantly and may allow proper early post-operative care optimization. Graphical Abstract