Rectal cancer lexicon 2023 revised and updated consensus statement from the Society of Abdominal Radiology Colorectal and Anal Cancer Disease-Focused Panel

• Published in: Abdominal imaging Vol. 48; no. 9; pp. 2792 - 2806
• Main Authors: Lee, Sonia, Kassam, Zahra, Baheti, Akshay D., Hope, Thomas A., Chang, Kevin J., Korngold, Elena K., Taggart, Melissa W., Horvat, Natally
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2023; Springer Nature B.V
• Subjects: Anal cancer; Anus; Cancer; Classification systems; Clinical significance; Colorectal cancer; Gastroenterology; Health services; Hepatology; Imaging; Language; Lymph nodes; Lymphatic system; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Radiology; Rectum; Special Section: Rectal Cancer; Sphincter; Terminology; Tumors; Oncology; Rectal adenocarcinoma; Gastrointestinal tract; Rectal cancer; MRI
• ISSN: 2366-0058; 2366-004X; 2366-0058
• DOI: 10.1007/s00261-023-03893-2

The Society of Abdominal Radiology’s Colorectal and Anal Cancer Disease-Focused Panel (DFP) first published a rectal cancer lexicon paper in 2019. Since that time, the DFP has published revised initial staging and restaging reporting templates, and a new SAR user guide to accompany the rectal MRI synoptic report (primary staging). This lexicon update summarizes interval developments, while conforming to the original lexicon 2019 format. Emphasis is placed on primary staging, treatment response, anatomic terminology, nodal staging, and the utility of specific sequences in the MRI protocol. A discussion of primary tumor staging reviews updates on tumor morphology and its clinical significance, T1 and T3 subclassifications and their clinical implications, T4a and T4b imaging findings/definitions, terminology updates on the use of MRF over CRM, and the conundrum of the external sphincter. A parallel section on treatment response reviews the clinical significance of near-complete response and introduces the lexicon of “regrowth” versus “recurrence”. A review of relevant anatomy incorporates updated definitions and expert consensus of anatomic landmarks, including the NCCN’s new definition of rectal upper margin and sigmoid take-off. A detailed review of nodal staging is also included, with attention to tumor location relative to the dentate line and locoregional lymph node designation, a new suggested size threshold for lateral lymph nodes and their indications for use, and imaging criteria used to differentiate tumor deposits from lymph nodes. Finally, new treatment terminologies such as organ preservation, TNT, TAMIS and watch-and-wait management are introduced. This 2023 version aims to serve as a concise set of up-to-date recommendations for radiologists, and discusses terminology, classification systems, MRI and clinical staging, and the evolving concepts in diagnosis and treatment of rectal cancer. Graphical abstract