Selective activations and functional connectivities to the sight of faces, scenes, body parts and tools in visual and non-visual cortical regions leading to the human hippocampus

• Published in: Brain Structure and Function Vol. 229; no. 6; pp. 1471 - 1493
• Main Authors: Rolls, Edmund T., Feng, Jianfeng, Zhang, Ruohan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2024; Springer Nature B.V
• Subjects: Adult; Biomedical and Life Sciences; Biomedicine; Brain Mapping; Brain research; Cell Biology; Connectome; Face; Female; Functional magnetic resonance imaging; Hippocampus - diagnostic imaging; Hippocampus - physiology; Humans; Magnetic Resonance Imaging; Male; Motion detection; Neural networks; Neural Pathways - physiology; Neurology; Neurosciences; Original; Original Article; Pattern Recognition, Visual - physiology; Photic Stimulation; Prefrontal cortex; Sensory integration; Somatosensory cortex; Superior temporal sulcus; Temporal lobe; Visual Cortex - diagnostic imaging; Visual Cortex - physiology; Visual Perception - physiology; Visual stimuli; Young Adult; Human visual cortex; Ventromedial visual cortical stream; Cortical scene regions; Human connectome; Human visual pathways; Activations to faces, places, body parts, and tools
• ISSN: 1863-2661; 1863-2653; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-024-02811-6

Connectivity maps are now available for the 360 cortical regions in the Human Connectome Project Multimodal Parcellation atlas. Here we add function to these maps by measuring selective fMRI activations and functional connectivity increases to stationary visual stimuli of faces, scenes, body parts and tools from 956 HCP participants. Faces activate regions in the ventrolateral visual cortical stream (FFC), in the superior temporal sulcus (STS) visual stream for face and head motion; and inferior parietal visual (PGi) and somatosensory (PF) regions. Scenes activate ventromedial visual stream VMV and PHA regions in the parahippocampal scene area; medial (7m) and lateral parietal (PGp) regions; and the reward-related medial orbitofrontal cortex. Body parts activate the inferior temporal cortex object regions (TE1p, TE2p); but also visual motion regions (MT, MST, FST); and the inferior parietal visual (PGi, PGs) and somatosensory (PF) regions; and the unpleasant-related lateral orbitofrontal cortex. Tools activate an intermediate ventral stream area (VMV3, VVC, PHA3); visual motion regions (FST); somatosensory (1, 2); and auditory (A4, A5) cortical regions. The findings add function to cortical connectivity maps; and show how stationary visual stimuli activate other cortical regions related to their associations, including visual motion, somatosensory, auditory, semantic, and orbitofrontal cortex value-related, regions.