Prevalence of higher-grade dysplasia in persistently high-risk human papillomavirus positive, cytology negative women after introduction of the new cervical cancer screening in Germany

• Published in: Cancer causes & control Vol. 34; no. 5; pp. 469 - 477
• Main Authors: Berger, Laura, Wolf-Breitinger, Maja, Weiß, Christel, Tuschy, Benjamin, Berlit, Sebastian, Sütterlin, Marc, Spaich, Saskia
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2023; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Biopsy; Cancer; Cancer Research; Cancer screening; Cellular biology; Cervical cancer; Colposcopy; Cytology; Dysplasia; Early Detection of Cancer; Epidemiology; Female; Genotypes; Genotyping; Hematology; Human papillomavirus; Human papillomavirus 16; Human Papillomavirus Viruses; Humans; Male; Mass Screening; Medical screening; Oncology; Original Paper; Papillomaviridae - genetics; Papillomavirus Infections - diagnosis; Papillomavirus Infections - epidemiology; Pregnancy; Prevalence; Public Health; Retrospective Studies; Risk; Uterine Cervical Dysplasia - epidemiology; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - pathology; Viruses; Germany; VaIN; CIN; Cervical cancer screening; hrHPV; Colposcopy; Negative cytology
• ISSN: 0957-5243; 1573-7225; 1573-7225
• DOI: 10.1007/s10552-023-01677-z

Purpose According to the recently implemented organized cervical cancer screening program in Germany, women older than 35 years with negative cytology but persistent high-risk human papilloma virus (hrHPV) infection > 12 months should be referred to colposcopy for further evaluation. This study aimed to present and dissect colposcopic and histopathological findings with particular focus on associated hrHPV genotypes. Methods This study is a retrospective analysis of clinical data from 89 hrHPV positive patients with normal cytology who underwent colposcopic examination at a certified dysplasia outpatient clinic in Germany in 2021. Results While 38 (43%) women had a normal colposcopic finding, 45 (51%) had minor and 6 (7%) major changes. Thirty-one (35%) of the women were HPV 16 and/or HPV 18 positive and 58 (65%) women were positive for other hrHPV only. Among patients who underwent colposcopy with biopsies (in case of an abnormal finding or type 3 transformation zone, n  = 68), eight (12%) had cervical intraepithelial neoplasia (CIN) 3 and six (9%) had CIN 2. The proportion of women diagnosed with CIN 3 varied among different hrHPV genotypes (HPV 16: 11%, HPV 18: 33%, HPV 31: 27%, HPV 33: 33%, HPV 52: 33%). Conclusion Persistently hrHPV positive women with negative cytology are at increased risk of being diagnosed with CIN 3. As CIN 3 prevalence seems to differ with regard to hrHPV strain, immediate HPV genotyping for risk stratification and subsequent early referral for colposcopy might constitute a feasible strategy.