Low frequency of acute hepatitis E virus (HEV) infections but high past HEV exposure in subjects from Cambodia with mild liver enzyme elevations, unexplained fever or immunodeficiency due to HIV-1 infection

• Published in: Journal of clinical virology Vol. 71; pp. 22 - 27
• Main Authors: Nouhin, Janin, Barennes, Hubert, Madec, Yoann, Prak, Sophearot, Hou, Serey Vannak, Kerleguer, Alexandra, Kim, Saorin, Pean, Polidy, Rouet, François
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2015; Elsevier
• Subjects: Adolescent; Adult; Aged; Allergy and Immunology; Cambodia; Cambodia - epidemiology; Child; Child, Preschool; Enzymes - blood; Female; Hepatitis Antibodies - blood; Hepatitis E - epidemiology; Hepatitis E - pathology; Hepatitis E virus; Hepatitis E virus - genetics; Hepatitis E virus - immunology; Hepatitis E virus - isolation & purification; Hepeviridae; HEV; HIV Infections - complications; Human health and pathology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immunoglobulin G - blood; Immunoglobulin M - blood; Infant; Infant, Newborn; Infectious Disease; Infectious diseases; Lentivirus; Life Sciences; Liver - enzymology; Liver Function Tests; Male; Middle Aged; Prevalence; Retrospective Studies; Retroviridae; RNA, Viral - blood; Young Adult; Cambodia; Cambodia; HEV
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2015.07.304

Highlights • HEV infection was retrospectively assessed in 825 Cambodian subjects. • We found an overall anti-HEV IgM prevalence rate of 1.1%. • No subject tested positive for HEV RNA. • A high (30%) anti-HEV IgG prevalence rate was obtained. • Recent HEV infections were rare, contrasting with a high level of past HEV exposure.