Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma

• Published in: Cancer epidemiology Vol. 36; no. 3; pp. 283 - 287
• Main Authors: Li, Shanqu, Jin, Tianbo, Zhang, Jiayi, Lou, Huiling, Yang, Bo, Li, Yang, Chen, Chao, Zhang, Yongsheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2012; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group - genetics; Cancer; Case–control study; CCDC26; Child; Child, Preschool; China; Epidemiology; Female; Genetic Predisposition to Disease; Glioma; Glioma - genetics; Hematology, Oncology and Palliative Medicine; Humans; IL4R; Interleukin-4 Receptor alpha Subunit - genetics; Internal Medicine; Intracellular Signaling Peptides and Proteins - genetics; Male; Middle Aged; Models, Genetic; Polymorphism, Single Nucleotide; Single nucleotide polymorphism (SNP); TREH; Trehalase - genetics; Young Adult; China; IL4R; Glioma; Single nucleotide polymorphism (SNP); Case–control study; TREH; CCDC26
• ISSN: 1877-7821; 1877-783X
• DOI: 10.1016/j.canep.2011.12.011

Abstract Introduction : Glioma is one of the most aggressive human tumors; however, little is known about its genetic risk factors. The role of heredity is likely to be explained by combinations of common low-risk variants. Previous studies have indicated that more than 100 single nucleotide polymorphisms (SNPs) are associated with the risk of glioma. Methods : To further investigate how and to what extent these SNPs contribute to glioma susceptibility in a Chinese population, we analyzed 43 SNPs of 226 glioma patients and 254 normal people in order to evaluate the associations between SNPs and the risk of glioma. Results : Overall, we found three protective alleles for glioma in patients: the allele “G” of rs1801275 in the IL4R gene by allele model (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.50–0.99; P = 0.04) and dominant model (OR, 0.67; 95% CI, 0.46–0.99; P = 0.04) analysis respectively, the allele “T” of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23–1.01; P = 0.05) analysis, and the allele “G” of rs6470745 in CCDC26 gene by recessive model (OR, 0.48; 95% CI, 0.26–0.89; P = 0.02) analysis. Conclusion : This study provides evidence for three glioma susceptibility genes – TREH, IL4R and CCDC26 – in a Chinese population; this may shed light on molecular markers of glioma susceptibility and could therefore be used as a diagnostic and prognostic marker for glioma patients in clinical study.