Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

• Published in: Pathologie biologie (Paris) Vol. 55; no. 1; pp. 37 - 48
• Main Authors: Paulsson, K., Johansson, B.
• Format: Journal Article
• Language: English
• Published: France Elsevier SAS 01.02.2007
• Subjects: Acute Disease; Acute myeloid leukemia; Adolescent; Adult; Basic Medicine; Cell Lineage; Cell Transformation, Neoplastic - genetics; chromosomal aberration; Chromosomes, Human, Pair 8; Cocarcinogenesis; Female; Gene Dosage; Genes, Neoplasm; Genomic Imprinting; Humans; Immunophenotyping; Karyotyping; Leukemia, Myeloid - epidemiology; Leukemia, Myeloid - genetics; Male; Medical and Health Sciences; Medical Genetics; Medicin och hälsovetenskap; Medicinsk genetik; Medicinska och farmaceutiska grundvetenskaper; Middle Aged; Myelodysplastic syndrome; Myelodysplastic Syndromes - epidemiology; Myelodysplastic Syndromes - genetics; Neoplastic Stem Cells - chemistry; Neoplastic Stem Cells - ultrastructure; Prognosis; sole; Sole chromosomal aberration; Trisomy; Trisomy 8; AML; Sole chromosomal aberration; ALL; CML; SCT; UPD; RAEB; Myelodysplastic syndrome; RA; SNP; CMML; FISH; CT8M; Acute myeloid leukemia; MDS; Trisomy 8
• ISSN: 0369-8114; 1768-3114
• DOI: 10.1016/j.patbio.2006.04.007

Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abnormalities, cell of origin, and functional and pathogenetic consequences. Here, we summarize and review these various aspects of trisomy 8, focusing on AMLs and MDS harboring this abnormality as a single change.