Impairment of oculomotor functions in patients with early to advanced amyotrophic lateral sclerosis

• Published in: Journal of neurology Vol. 271; no. 1; pp. 325 - 339
• Main Authors: Aust, Elisa, Graupner, Sven-Thomas, Günther, René, Linse, Katharina, Joos, Markus, Grosskreutz, Julian, Prudlo, Johannes, Pannasch, Sebastian, Hermann, Andreas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2024; Springer Nature B.V
• Subjects: Amyotrophic Lateral Sclerosis; Brain stem; Eye Movements; Humans; Medicine; Medicine & Public Health; Mesencephalon; Neurology; Neuroradiology; Neurosciences; Original Communication; Pursuit, Smooth; Saccades; Saccadic eye movements; Smooth pursuit eye movements; Oculomotor function; Saccades; Amyotrophic lateral sclerosis; Executive function; Eye movements; Eye tracking communication systems
• ISSN: 0340-5354; 1432-1459; 1432-1459
• DOI: 10.1007/s00415-023-11957-y

Amyotrophic lateral sclerosis (ALS) can result into an incomplete locked in state (iLIS), in which communication depends on eye tracking computer devices. Oculomotor function impairments in ALS have been reported, but there is little research, particularly with respect to patients in iLIS. In the present study, we compared reflexive and executive oculomotor function by means of an eye tracking test battery between three groups: advanced ALS patients in iLIS (n = 22), patients in early to middle ALS stages (n = 44) and healthy subjects (n = 32). Patients with ALS showed significant deteriorations in oculomotor functions, with stronger impairments in iLIS. More specifically, ALS patients produced visually guided prosaccades with longer latencies and more frequent hypometria compared to healthy subjects. Longest latencies were obtained in iLIS patients, with a stronger prolongation for vertical than for horizontal prosaccades. ALS patients made more antisaccade errors and generated antisaccades with longer latencies. Smooth pursuit was also impaired in ALS. In the earlier ALS stages, bulbar onset patients presented stronger antisaccade and smooth pursuit deficits than spinal onset patients. Our findings reveal a relevant deterioration of important oculomotor functions in ALS, which increases in iLIS. It includes impairments of reflexive eye movements to loss of executive inhibitory control, indicating a progressing pathological involvement of prefrontal, midbrain and brainstem areas. The assessment of oculomotor functions may therefore provide clinically relevant bio- and progression marker, particularly in advanced ALS.