A conserved germline multipotency program

The germline of multicellular animals is segregated from somatic tissues, which is an essential developmental process for the next generation. Although certain ecdysozoans and chordates segregate their germline during embryogenesis, animals from other taxa segregate their germline after embryogenesi...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 137; no. 24; pp. 4113 - 4126
Main Authors Juliano, Celina E, Swartz, S Zachary, Wessel, Gary M
Format Journal Article
LanguageEnglish
Published England Company of Biologists 15.12.2010
Subjects
Animals
Chordata
Embryonic Development - genetics
Embryonic Development - physiology
Gene Expression Regulation, Developmental - genetics
Gene Expression Regulation, Developmental - physiology
Germ Cells - cytology
Germ Cells - metabolism
Guanosine Monophosphate - metabolism
Hypothesis
Phylogeny
Sea Urchins - embryology
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Summary:The germline of multicellular animals is segregated from somatic tissues, which is an essential developmental process for the next generation. Although certain ecdysozoans and chordates segregate their germline during embryogenesis, animals from other taxa segregate their germline after embryogenesis from multipotent progenitor cells. An overlapping set of genes, including vasa, nanos and piwi, operate in both multipotent precursors and in the germline. As we propose here, this conservation implies the existence of an underlying germline multipotency program in these cell types that has a previously underappreciated and conserved function in maintaining multipotency.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.047969