Effect of Acute Myocardial Infarction on Erythrocytic Glutathione Peroxidase 1 Activity and Plasma Vitamin E Levels

• Published in: The American journal of cardiology Vol. 103; no. 4; pp. 471 - 475
• Main Authors: Cheng, Mei-ling, PhD, Chen, Chin-ming, MD, Ho, Hung-yao, PhD, Li, Jui-ming, MSc, Chiu, Daniel Tsun-yee, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.02.2009; Elsevier; Elsevier Limited
• Subjects: Aged; Antioxidants; Asian people; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Case-Control Studies; Coronary heart disease; Correlation analysis; Erythrocytes - enzymology; Female; Glutathione Peroxidase - metabolism; Heart; Heart attacks; Humans; Incidence; Male; Medical sciences; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - enzymology; Myocardial Infarction - epidemiology; Myocarditis. Cardiomyopathies; Studies; Taiwan; Vitamin E; Vitamin E - blood; Taiwan; Glutathione peroxidase; Myocardial infarction; Enzyme; Acute; Vitamin; Red blood cell; Cardiovascular disease; Activity; Coronary heart disease; Myocardial disease; Blood plasma; Peroxidases; Level; Oxidoreductases; Circulatory system; Cardiology
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2008.09.104

Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 ± 9.2 vs 47.3 ± 16.6 U/g hemoglobin; p <0.001). There was a significant inverse correlation between GPX-1 activity and acute myocardial infarction incidence (p = 0.032). In addition, plasma vitamin E inversely correlated with acute myocardial infarction incidence (p = 0.017). The incidence of acute myocardial infarction increased only in patients with low plasma vitamin E and low erythrocytic GPX-1 activity, but not in those with high vitamin E and low GPX-1 activity, low vitamin E and high GPX-1 activity, or high vitamin E and high GPX-1 activity. In conclusion, acute myocardial infarction incidence significantly increased in patients with a concomitant decrease in plasma vitamin E and erythrocytic GPX-1 activity, suggesting that both GPX-1 and vitamin E may be valuable markers for monitoring cardiovascular events, particularly when used in combination.