Stage-specific incidence rates and trends of prostate cancer by age, race, and ethnicity, United States, 2004–2014

• Published in: Annals of epidemiology Vol. 28; no. 5; pp. 328 - 330
• Main Authors: Li, Jun, Siegel, David A., King, Jessica B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2018
• Subjects: Age Distribution; Aged; Aged, 80 and over; Cancer incidence; Cancer stage; Continental Population Groups - statistics & numerical data; Ethnic Groups - statistics & numerical data; Humans; Incidence; Male; Middle Aged; Neoplasm Staging; Prostate cancer; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - pathology; Registries; SEER Program; United States - epidemiology; United States; Cancer stage; Cancer incidence; Prostate cancer
• ISSN: 1047-2797; 1873-2585
• DOI: 10.1016/j.annepidem.2018.03.001

Current literature shows different findings on the contemporary trends of distant-stage prostate cancer incidence, in part, due to low study population coverage and wide age groupings. This study aimed to examine the stage-specific incidence rates and trends of prostate cancer by age (5-year grouping), race, and ethnicity using nationwide cancer registry data. Data on prostate cancer cases came from the 2004–2014 United States Cancer Statistics data set. We calculated stage-specific incidence and 95% confidence intervals by age (5-year age grouping), race, and ethnicity. To measure the changes in rates over time, we calculated annual percentage change (APC). We identified 2,137,054 incident prostate cancers diagnosed during 2004–2014, with an age-adjusted incidence rate of 453.8 per 100,000. Distant-stage prostate cancer incidence significantly decreased during 2004–2010 (APC = −1.2) and increased during 2010–2014 (APC = 3.3). Significant increases in distant prostate cancer incidence also occurred in men aged older than or equal to 50 years except men aged 65–74 and older than or equal to 85 years, in men with white race (APC = 3.9), and non-Hispanic ethnicity (APC = 3.5). Using data representing over 99% of U.S. population, we found that incidence rates of distant-stage prostate cancer significantly increased during 2010–2014 among men in certain ages, in white, and with non-Hispanic ethnicity.