Cardiac adaptation to chronic high-altitude hypoxia: Beneficial and adverse effects
Abstract This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial chang...
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| Published in | Respiratory physiology & neurobiology Vol. 158; no. 2; pp. 224 - 236 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
30.09.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Abstract This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial changes. Particular attention was paid to cardioprotective effects of adaptation to chronic high-altitude hypoxia and their molecular mechanisms. Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized. |
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| AbstractList | This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial changes. Particular attention was paid to cardioprotective effects of adaptation to chronic high-altitude hypoxia and their molecular mechanisms. Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized. Abstract This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial changes. Particular attention was paid to cardioprotective effects of adaptation to chronic high-altitude hypoxia and their molecular mechanisms. Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized. |
| Author | Ostadal, B Kolar, F |
| Author_xml | – sequence: 1 fullname: Ostadal, B – sequence: 2 fullname: Kolar, F |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17442631$$D View this record in MEDLINE/PubMed |
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| Keywords | Heart Permanent Intermittent Molecular mechanisms Reversibility High-altitude hypoxia Protection Age Adaptation Hypertrophy |
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| Snippet | Abstract This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From... This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad... |
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| SubjectTerms | Acclimatization - physiology Adaptation Age Age Factors Altitude Animals Atmospheric Pressure Chronic Disease Heart High-altitude hypoxia Hypertrophy Hypoxia - complications Hypoxia - metabolism Intermittent Ischemia - etiology Ischemia - metabolism Medical Education Molecular mechanisms Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - metabolism Myocardium - metabolism Oxygen - blood Permanent Protection Pulmonary/Respiratory Reversibility |
| Title | Cardiac adaptation to chronic high-altitude hypoxia: Beneficial and adverse effects |
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