Treatment of hydrocephalus following posterior fossa tumor resection: a multicenter collaboration from the Hydrocephalus Clinical Research Network

• Published in: Journal of neuro-oncology Vol. 163; no. 1; pp. 123 - 132
• Main Authors: Dewan, Michael C., Isaacs, Albert M., Cools, Michael J, Yengo-Kahn, Aaron, Naftel, Robert P., Jensen, Hailey, Reeder, Ron W, Holubkov, Richard, Haizel-Cobbina, Joseline, Riva-Cambrin, Jay, Jafrani, Ryan J, Pindrik, Jonathan A, Jackson, Eric M., Judy, Brendan F, Kurudza, Elena, Pollack, Ian F., Mcdowell, Michael M., Hankinson, Todd C., Staulcup, Susan, Hauptman, Jason, Hall, Koko, Tamber, Mandeep S, Cheong, Alex, Warsi, Nebras M., Rocque, Brandon G., Saccomano, Benjamin W, Snyder, Rita I, Kulkarni, Abhaya V., Kestle, John R. W., Wellons, John C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2023; Springer Nature B.V
• Subjects: Brain cancer; Brain tumors; Cerebrospinal fluid; Child; Failure; Humans; Hydrocephalus; Hydrocephalus - epidemiology; Hydrocephalus - etiology; Hydrocephalus - surgery; Infratentorial Neoplasms - complications; Infratentorial Neoplasms - surgery; Medicine; Medicine & Public Health; Morbidity; Neuroendoscopy - adverse effects; Neurology; Oncology; Patients; Pediatrics; Retrospective Studies; Treatment Outcome; Ventriculoperitoneal Shunt - adverse effects; Ventriculostomy - adverse effects; Endoscopic third ventriculostomy; Hydrocephalus; Ventriculoperitoneal shunt; Posterior fossa tumor
• ISSN: 0167-594X; 1573-7373; 1573-7373
• DOI: 10.1007/s11060-023-04316-4

Objective Persistent hydrocephalus following posterior fossa brain tumor (PFBT) resection is a common cause of morbidity in pediatric brain tumor patients, for which the optimal treatment is debated. The purpose of this study was to compare treatment outcomes between VPS and ETV in patients with persistent hydrocephalus following surgical resection of a PFBT. Methods A post-hoc analysis was performed of the Hydrocephalus Clinical Research Network (HCRN) prospective observational study evaluating VPS and ETV for pediatric patients. Children who experienced hydrocephalus secondary to PFBT from 2008 to 2021 were included. Primary outcomes were VPS/ETV treatment failure and time-to-failure (TTF). Results Among 241 patients, the VPS (183) and ETV (58) groups were similar in age, extent of tumor resection, and preoperative ETV Success Score. There was no difference in overall treatment failure between VPS and ETV (33.9% vs 31.0%, p = 0.751). However, mean TTF was shorter for ETV than VPS (0.45 years vs 1.30 years, p = 0.001). While major complication profiles were similar, compared to VPS, ETV patients had relatively higher incidence of minor CSF leak (10.3% vs. 1.1%, p = 0.003) and pseudomeningocele (12.1% vs 3.3%, p = 0.02). No ETV failures were identified beyond 3 years, while shunt failures occurred beyond 5 years. Shunt infections occurred in 5.5% of the VPS cohort. Conclusions ETV and VPS offer similar overall success rates for PFBT-related postoperative hydrocephalus. ETV failure occurs earlier, while susceptibility to VPS failure persists beyond 5 years. Tumor histology and grade may be considered when selecting the optimal means of CSF diversion.