Cognitive control enhancement in attention deficit hyperactivity disorder (ADHD) and neurotypical individuals

• Published in: Experimental brain research Vol. 241; no. 9; pp. 2381 - 2392
• Main Authors: Weinberg, Hodaya, Baruch, Yuval, Tzameret, Hila, Lavidor, Michal
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2023; Springer; Springer Nature B.V
• Subjects: Analysis; Attention Deficit Disorder with Hyperactivity - therapy; Attention deficit hyperactivity disorder; Biomedical and Life Sciences; Biomedicine; brain; Care and treatment; Cognition; Cognitive ability; Diagnosis; Electrical stimulation of the brain; Electrodes; ESB; Frontal gyrus; Humans; image analysis; Language; languages; Neuroimaging; Neurology; Neurosciences; patients; prediction; Research Article; Transcranial Direct Current Stimulation; Israel; ADHD; rIFG; tDCS; Cognitive control
• ISSN: 0014-4819; 1432-1106; 1432-1106
• DOI: 10.1007/s00221-023-06695-6

Cognitive control, which has been localized to the right inferior frontal gyrus (rIFG) based on functional imaging and brain lesion studies, is impaired in patients with ADHD. The present study aims to investigate whether transcranial direct current stimulation (tDCS) over the rIFG might improve cognitive control in ADHD subjects. We hypothesized poorer performance in a cognitive control task, but not in a control language task, in the ADHD subjects. Crucially, following tDCS, we expected the ADHD group to improve their cognitive control. In a double-blind randomized control trial, 42 participants performed the stop signal task (SST) to index their cognitive control level and the language task. Half of them were randomly assigned to the anodal stimulation condition and half to the sham stimulation. The anodal or sham stimulation was applied over the right IFG. Following the stimulation, the participants reset the two tasks to see whether stimulation improved the (predicted) weaker performance in the ADHD group. Stimulation significantly enhanced cognitive control for both groups, with or without ADHD, in the SST task, but no significant stimulation effects were found for the control task. tDCS seems as a promising tool to improve cognitive control in the general population.