A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD)

A metabonomics study based on GC/MS and multivariate statistical analysis was performed involving 28 post stroke depressed (PSD) patients, 27 post-stroke non-depressed (PSND) patients and 33 healthy subjects to investigate the biochemical perturbation in their plasma samples. The outcome of this stu...

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Published inMetabolic brain disease Vol. 31; no. 2; pp. 279 - 287
Main Authors Ding, Xinghua, Liu, Ruoxu, Li, Wenkai, Ni, Hengjia, Liu, Yong, Wu, Dandan, Yang, Shuguang, Liu, Jing, Xiao, Bo, Liu, Shaojun
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2016
Springer Nature B.V
Subjects
Adult
Aged
Biochemistry
Biomedical and Life Sciences
Biomedicine
Depression - blood
Depressive Disorder - complications
Depressive Disorder - etiology
Female
Humans
Male
Metabolic Diseases
Metabolomics - methods
Middle Aged
Neurology
Neurosciences
Oncology
Original Article
Stroke - blood
Stroke - complications
Stroke Rehabilitation
Stroke rehabilitation
Metabonomics
GC/MS
Post-stroke depression
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Summary:A metabonomics study based on GC/MS and multivariate statistical analysis was performed involving 28 post stroke depressed (PSD) patients, 27 post-stroke non-depressed (PSND) patients and 33 healthy subjects to investigate the biochemical perturbation in their plasma samples. The outcome of this study showed that there was distinctive metabolic profile for PSD patients. Seven sentinel metabolites showed marked perturbations in PSD patients' blood. The introduction of metabonomics approach may provide a novel metabonomic insight about PSD and the sentinel metabolites for classifying PSD.
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ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-015-9748-z