Postdelivery changes in maternal and infant erythrocyte fatty acids in 3 populations differing in fresh water fish intakes

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 85; no. 6; pp. 387 - 397
• Main Authors: Kuipers, Remko S, Luxwolda, Martine F, Sango, Wicklif S, Kwesigabo, Gideon, Janneke Dijck-Brouwer, D.A, Muskiet, Frits A.J
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2011; Elsevier
• Subjects: Acetyltransferases - metabolism; Adult; Advanced Basic Science; Animals; Biological and medical sciences; Case-Control Studies; De novo lipogenesis; Diet; Dietary Fats - metabolism; Docosahexaenoic acid; Endocrinology & Metabolism; Erythrocyte; Erythrocytes - enzymology; Erythrocytes - metabolism; Fatty Acid Desaturases - metabolism; Fatty acids; Fatty Acids, Unsaturated - metabolism; Female; Fish; Fishes; Fresh Water; Freshwater; Fundamental and applied biological sciences. Psychology; Humans; Infant; Infant, Newborn; Lipogenesis; Male; Meat; Middle Aged; Milk, Human - metabolism; Pregnancy; Tanzania; Vertebrates: endocrinology; Young Adult; Africa; Tanzania; PP; DNL; RBC; VLDL; postpartum; saturated fatty acids; AA; arachidonic acid; PUFA; carbohydrate responsive element binding protein; De novo lipogenesis; Tanzania; SCD-1; FADS; monounsaturated fatty acids; erythrocyte; SAFA; eicosapentaenoic acid; stearoyl-coenzyme A desaturase family member 1; α-linolenic acid; fatty acid synthase; very low density lipoprotein; FA; DHA; de novo lipid synthesis or de novo lipogenesis; elongation of very long chained fatty acids family member 6; EFA; acetyl-Coenzyme A carboxylase; SREBP-1; LXR; MUFA; polyunsaturated fatty acids; Elovl-6; Freshwater; sterol regulatory element binding protein-1; docosahexaenoic acid; Fish; ACC; liver-X-receptor; fatty acids; linoleic acid; essential fatty acids; Pregnancy; ChREBP; LA; ALA; EPA; fatty acid desaturase; FAS; Docosahexaenoic acid; Fatty acids; Erythrocyte; Polyunsaturated fatty acid; Red blood cell; Lipids; n-3 fatty acid; De novo; Blood cell; Unsaturated fatty acid; Water intake; Lipogenesis
• ISSN: 0952-3278; 1532-2823
• DOI: 10.1016/j.plefa.2011.06.004

Abstract Introduction Long-chain polyunsaturated (LCP) fatty acids (FA) are important during infant development. Mother-to-infant FA-transport occurs at the expense of the maternal status. Maternal and infant FA-status change rapidly after delivery. Methods Comparison of maternal (mRBC) and infant erythrocyte (iRBC)-FA-profiles at delivery and after 3 months exclusive breastfeeding in relation to freshwater-fish intakes. Approximation of de-novo -lipogenesis (DNL), stearoyl-CoA-desaturase (SCD), elongation-of-very-long-chain-FA-family-member-6 (Elovl-6), delta-5-desaturase (D5D) and delta-6-desaturase (D6D)-enzymatic activities from their product/essential-FA and product/substrate-ratios. Results and discussion Increasing iRBC-14:0 derived from mammary-gland DNL. Decreasing mRBC-ω9, but increasing iRBC-ω9, suggest high ω9-FA-transfer via breastmilk. Decreasing (m+i)RBC-16:0, DNL- and SCD-activities, but increasing (m+i)RBC-18:0 and Elovl-6-activity suggest more pronounced postpartum decreases in DNL- and SCD-activities, compared to Elovl-6-activity. Increasing (m+i)RBC-18:3ω3, 20:5ω3, 22:5ω3, 18:2ω6, mRBC-20:4ω6 and (m+i)D5D-activity, but decreasing mRBC-22:6ω3 and (m+i)D6D-activity and dose-dependent changes in iRBC-22:6ω3 confirm that D6D-activity is rate-limiting and 22:6ω3 is important during lactation. Fish-intake related magnitudes of postpartum FA-changes suggest that LCPω3 influence DNL-, SCD- and desaturase-activities.