Anal human papillomavirus and HIV: A cross-sectional study among men who have sex with men in Moscow, Russia, 2012-2013

• Published in: Euro surveillance : bulletin européen sur les maladies transmissibles Vol. 20; no. 15; p. 1
• Main Authors: Wirtz, A L, Zelaya, C E, Peryshkina, A, McGowan, I, Cranston, R D, Latkin, C, Galai, N, Mogilniy, V, Dzhigun, P, Kostetskaya, I, Beyrer, C
• Format: Journal Article
• Language: English
• Published: Sweden Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) 16.04.2015
• Subjects: Adolescent; Adult; Anal Canal - virology; Anus Diseases - epidemiology; Anus Diseases - prevention & control; Anus Diseases - virology; Coinfection - epidemiology; Coinfection - virology; Confidence intervals; Cross-Sectional Studies; Gays & lesbians; Genotype; HIV; HIV Infections - epidemiology; HIV Infections - virology; Homosexuality, Male - statistics & numerical data; Human immunodeficiency virus; Human papillomavirus; Humans; Logistic Models; Male; Men; Middle Aged; Moscow - epidemiology; Multivariate Analysis; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - pathology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - virology; Prevalence; Regression analysis; Risk Factors; Sexual Behavior; Surveys and Questionnaires; Young Adult; Moscow; Moscow Russia
• ISSN: 1560-7917; 1025-496X; 1560-7917
• DOI: 10.2807/1560-7917.es2015.20.15.21095

Anal human papillomavirus (HPV) is prevalent among men who have sex with men (MSM), but has not been studied in the Russian Federation. A cross-sectional survey and HPV genotyping were conducted among HIV seropositive (n=58) and seronegative MSM (n=65)in Moscow. Multivariable logistic regression was performed to identify correlates of infection with oncogenic HPV genotypes 16 and/or 18 (HPV 16/18). Forty per cent (49/124) of all MSM were infected with at least one anal HPV genotype, 31.5% (39/124) had HPV16/18,and 11.5% (14/121) had high-grade squamous intraepithelial lesions (HSIL). HPV 16/18 was more prevalent in HIV seropositive than seronegative men (24/58,41.4% vs 15/65, 23.1%; p=0.03). HIV infection was independently associated with HPV 16/18 (adjusted odds ratio (AOR): 5.08; 95% confidence intervals (CI):1.49-17.34, p=0.01), as was having 2-4 steady male sex partners in the last year (vs ≤ 1 partner; AOR: 6.99;95%CI: 1.94–25.24, p<0.01). History of prison/detention,migration to/within Russia and use of incompatible lubricants were marginally associated with HPV16/18 (p<0.10). Comprehensive prevention options are needed to address HIV and HPV infection among MSM in Russia and may benefit from inclusion of young men in piloted HPV vaccination programmes.