Thyroid effects of endocrine disrupting chemicals

• Published in: Molecular and cellular endocrinology Vol. 355; no. 2; pp. 240 - 248
• Main Authors: Boas, Malene, Feldt-Rasmussen, Ulla, Main, Katharina M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 22.05.2012
• Subjects: animal experimentation; Animals; bisphenol A; Chemicals; EDC; Endocrine disrupters; Endocrine Disruptors - pharmacology; Endocrine Disruptors - toxicity; endocrine-disrupting chemicals; Environmental Exposure; exposure scenario; Female; flame retardants; Flame Retardants - pharmacology; Flame Retardants - toxicity; Humans; in vitro studies; infants; Male; Maternal Exposure; mechanism of action; perfluorocarbons; Pesticides - pharmacology; Pesticides - toxicity; phthalates; polychlorinated biphenyls; Pregnancy; pregnant women; Reproductive Health; Thyroid; Thyroid Gland - drug effects; Thyroid Gland - metabolism; thyroid hormones; Thyroid Hormones - physiology; Thyroxine; NP; MEHP; EDC; TRE; 4-MBC; TCDD; Endocrine disrupters; PFC; PBB; TPO; DBP; TTR; DDT; DEHP; PBDE; PCDD; Thyroxine; TBG; MBP; T3; Thyroid; T4; BP3; OMC; BP2; HCB; TSH; PFOA; PCB; Chemicals; BPA; NIS; TBBPA; TR; PFOS
• ISSN: 0303-7207; 1872-8057; 1872-8057
• DOI: 10.1016/j.mce.2011.09.005

► Humans are exposed to a large number of suspected thyroid disrupting chemicals. ► Exposure to PCBs and perchlorate has negative effects on thyroid function. ► BPA, UV-filters and phthalates are also suspected to be thyroid disrupting chemicals. ► Long term studies on thyroid effects in humans are currently lacking. In recent years, many studies of thyroid-disrupting effects of environmental chemicals have been published. Of special concern is the exposure of pregnant women and infants, as thyroid disruption of the developing organism may have deleterious effects on neurological outcome. Chemicals may exert thyroid effects through a variety of mechanisms of action, and some animal experiments and in vitro studies have focused on elucidating the mode of action of specific chemical compounds. Long-term human studies on effects of environmental chemicals on thyroid related outcomes such as growth and development are still lacking. The human exposure scenario with life long exposure to a vast mixture of chemicals in low doses and the large physiological variation in thyroid hormone levels between individuals render human studies very difficult. However, there is now reasonably firm evidence that PCBs have thyroid-disrupting effects, and there is emerging evidence that also phthalates, bisphenol A, brominated flame retardants and perfluorinated chemicals may have thyroid disrupting properties.