Assessment of macular microvascular changes in children following treatment of anisometropic myopic amblyopia using optical coherence tomography angiography

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 261; no. 9; pp. 2689 - 2699
• Main Authors: AttaAllah, Heba Radi, Abdelaziz, Sahar Torky Abdelrazik, Mohamed, Asmaa Anwar Mohamed, Ibrahiem, Mohamed Farag Khalil
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2023; Springer Nature B.V
• Subjects: Acuity; Amblyopia - diagnosis; Amblyopia - therapy; Angiography; Child; Eye; Female; Fluorescein Angiography - methods; Humans; Male; Medical imaging; Medicine; Medicine & Public Health; Microvasculature; Myopia - complications; Myopia - diagnosis; Myopia - therapy; Ophthalmology; Patching; Patients; Pediatrics; Retina; Retinal Vessels; Tomography; Tomography, Optical Coherence - methods; Visual Acuity; Microvascular changes; Vessel density; Amblyopia treatment; Anisometropic amblyopia; OCTA; FAZ
• ISSN: 0721-832X; 1435-702X; 1435-702X
• DOI: 10.1007/s00417-023-06055-8

Purpose To evaluate macular microvascular changes in the form of foveal avascular zone (FAZ) area and vessel density in the superficial, deep capillary plexuses, and choriocapillaris using optical coherence tomography angiography (OCTA) in children with anisometropic myopic amblyopia before and after treatment. Methods This prospective observational study included 32 patients younger than 12 years old with anisomyopic amblyopia. OCTA was done before patients’ treatment with optical correction with or without patching and was repeated after successful amblyopia treatment. Outcomes included superficial, deep, and choriocapillaris vessel density (VD) and superficial and deep FAZ areas. Results The study included 13 males (40.6%) and 19 females (59.4%), and the mean age was 9.52 ± 1.33 years. Fifty-three percent (53%) of patients needed only optical correction, and the remaining 47% needed additional patching therapy. After successful treatment, there was a significant improvement in amblyopic eyes in best-corrected visual acuity ( p  < 0.001), with higher VD values in superficial capillary plexuses ( p  < 0.001), deep capillary plexuses ( p  < 0.001), and foveal choriocapillaris ( p  = 0.030). In the glasses with patching subgroup, the difference between pre-treatment and post-treatment parameters revealed a significant improvement in vessel density in superficial retinal plexuses (foveal and parafoveal; p values 0.023 and < 0.001, respectively) and deep retinal plexuses (whole image, foveal, and parafoveal; p values 0.003, < 0.001, and 0.002, respectively). While amblyopic eyes treated with glasses alone had a significantly greater difference in choriocapillaris foveal VD ( p value = 0.022). Conclusion After effective amblyopia treatment, amblyopic eyes exhibited improved best-corrected visual acuity and better macular perfusion along the superficial, deep vascular density, and choriocapillaris foveal VD. Clinical trial registration CinicalTrials.gov Identifier: NCT05223153.