The Mechanism of Bone Remodeling After Bone Aging

• Published in: Clinical interventions in aging Vol. 17; pp. 405 - 415
• Main Authors: Fang, Huankun, Deng, Zhiqin, Liu, Jianquan, Chen, Siyu, Deng, Zhenhan, Li, Wencui
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 30.04.2022; Dove; Dove Medical Press
• Subjects: Aging; autophagy; Autophagy (Cytology); bone formation; Bone Remodeling; Bones; chlorine channel; epigenetics; Genetic aspects; Health aspects; Humans; Osteoclasts - metabolism; Osteocytes - metabolism; osteoporosis; Osteoporosis - drug therapy; Physiological aspects; Review; China; bone formation; autophagy; aging; chlorine channel; osteoporosis; epigenetics
• ISSN: 1178-1998; 1176-9092; 1178-1998
• DOI: 10.2147/CIA.S349604

Senescence mainly manifests as a series of degenerative changes in the morphological structure and function of the body. Osteoporosis is a systemic bone metabolic disease characterized by destruction of bone microstructure, low bone mineral content, decreased bone strength, and increased brittleness and fracture susceptibility. Osteoblasts, osteoclasts and osteocytes are the main cellular components of bones. However, in the process of aging, due to various self or environmental factors, the body's function and metabolism are disordered, and osteoporosis will appear in the bones. Here, we summarize the mechanism of aging, and focus on the impact of aging on bone remodeling homeostasis, including the mechanism of ion channels on bone remodeling. Finally, we summarized the current clinical medications, targets and defects for the treatment of osteoporosis.