Intracellular transport of hepatitis B virus
For genome mulUplication hepadnaviruses use the transcriptional machinery of the cell that is found within the nucleus. Thus the viral genome has to be transported through the cytoplasm and nuclear pore. The intracytosolic translocation is facilitated by the viral capsid that surrounds the genome an...
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Published in | World journal of gastroenterology : WJG Vol. 13; no. 1; pp. 39 - 47 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
CNRS-REGER (UMR 5097), Université Bordeaux 2, 146 rue Léo Saignat, F-33076 Bordeaux Cedex, France%Institute of Medical Virology, Frankfurter Str. 107, D-35392 Giessen, Germany
07.01.2007
Baishideng Publishing Group Co. Limited Baishideng Publishing Group Co., Limited |
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Online Access | Get full text |
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Summary: | For genome mulUplication hepadnaviruses use the transcriptional machinery of the cell that is found within the nucleus. Thus the viral genome has to be transported through the cytoplasm and nuclear pore. The intracytosolic translocation is facilitated by the viral capsid that surrounds the genome and that interacts with cellular microtubules. The subsequent passage through the nuclear pore complexes (NPC) is mediated by the nuclear transport receptors importin α andβ. Importin α binds to the C-terminus of the capsid protein that comprises a nuclear localization signal (NLS). The exposure of the NLS is regulated and depends upon genome maturation and/or phosphorylation of the capsid protein. As for other karyophilic cargos using this pathway importin α interacts with importin β that facilitates docking of the import complex to the NPC and the passage through the pore. Being a unique strategy, the import of the viral capsid is incomplete in that it becomes arrested inside the nuclear basket, which is a cage-like structure on the karyoplasmic face of the NPC. Presumably only this compartment provides the factors that are required for capsid disassembly and genome release that is restricted to those capsids comprising a mature viral DNA genome. |
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Bibliography: | Nuclear basket Intracellular transport Nuclear pore 14-1219/R Microtubules Importin Nuclear localization signal Hepatitis B virus Capsid Hepatitis B virus; Capsid; Intracellular transport; Microtubules; Nuclear pore; Importin; Nuclear localization signal; Nuclear basket R512.62 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Telephone: +33-5-57574876 Fax: +33-5-57571766 Correspondence to: Michael Kann, MD, CNRS-REGER (UMR 5097), Bat 3A, Université Bordeaux 2, 146 rue Léo Saignat, F-33076 Bordeaux Cedex, France. michael.kann@u-bordeaux2.fr Author contributions: All authors contributed equally to the work. |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/wjg.v13.i1.39 |