Transient Serous Retinal Detachment in Classic and Occult Choroidal Neovascularization After Photodynamic Therapy

• Published in: American journal of ophthalmology Vol. 140; no. 4; pp. 758 - 760
• Main Authors: Mennel, Stefan, Meyer, Carsten H., Eggarter, Fred, Peter, Silvia
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2005; Elsevier; Elsevier Limited
• Subjects: Biological and medical sciences; Blood-Retinal Barrier; Choroidal Neovascularization - drug therapy; Exudates and Transudates; Humans; Macular degeneration; Medical sciences; Miscellaneous; Occult sciences; Ophthalmology; Photochemotherapy; Photodynamic therapy; Postoperative Complications; Prospective Studies; Retina; Retinal Detachment - diagnosis; Retinal Detachment - etiology; Retinopathies; Serum; Tomography, Optical Coherence - methods; Uvea diseases; Retinal detachment; Eye disease; Retinopathy; Photodynamic therapy; Treatment; Choroidal neovascularization; Uvea disease; Ophthalmology; Choroidal detachment; Transitory
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2005.04.041

To quantify transient serous retinal detachment in classic and occult choroidal neovascularization (CNV) after photodynamic therapy (PDT). Prospective consecutive case series. Consecutive patients with classic and occult CNV were examined by optical coherence tomography before PDT and at 2 and 7 days after PDT. In classic CNV (n = 6), retinal elevations increased from 217 (SD 42) μm before PDT to 626 (SD 157) μm 2 days after PDT and decreased to 240 (SD 36) μm 7 days after treatment. In occult CNV (n = 4), the mean retinal elevation of 266 (SD 41) μm before PDT increased to 544 (SD 94) μm 2 days after PDT and decreased to 259 (SD 40) μm 7 days after treatment. Cross-sectional optical coherence tomography imaging revealed transient subretinal fluid accumulation in classic as well as in occult CNV after PDT. The subretinal location possibly relates to an outer blood-retinal barrier breakdown after PDT.