Arterial spin labelling MRI for brain tumour surveillance: do we really need cerebral blood flow maps?

• Published in: European radiology Vol. 33; no. 11; pp. 8005 - 8013
• Main Authors: Teunissen, Wouter H. T., Lavrova, Anna, van den Bent, Martin, van der Hoorn, Anouk, Warnert, Esther A. H., Smits, Marion
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2023; Springer Nature B.V
• Subjects: Accuracy; Blood flow; Brain; Brain cancer; Brain mapping; Brain Neoplasms - pathology; Brain tumors; Cerebral blood flow; Cerebrovascular Circulation - physiology; Correlation; Diagnostic Radiology; Diagnostic systems; Flow mapping; Health surveillance; Humans; Imaging; Internal Medicine; Interventional Radiology; Labeling; Lesions; Lymphoma; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Mathematical analysis; Medicine; Medicine & Public Health; Metastases; Neuro; Neuroimaging; Neuroradiology; Perfusion; Radiology; Spin labeling; Spin Labels; Substantia alba; Surveillance; Tumors; Ultrasound; Workflow; Sensitivity and specificity; Brain; Brain neoplasms; Magnetic resonance imaging
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-023-10099-z

Objectives Arterial spin labelling (ASL) perfusion MRI is one of the available advanced MRI techniques for brain tumour surveillance. The first aim of this study was to investigate the correlation between quantitative cerebral blood flow (CBF) and non-quantitative perfusion weighted imaging (ASL-PWI) measurements. The second aim was to investigate the diagnostic accuracy of ASL-CBF and ASL-PWI measurements as well as visual assessment for identifying tumour progression. Methods A consecutive cohort of patients who underwent 3-T MRI surveillance containing ASL for treated brain tumours was used. ROIs were drawn in representative parts of tumours in the ASL-CBF maps and copied to the ASL-PWI. ASL-CBF ratios and ASL-PWI ratios of the tumour ROI versus normal appearing white matter (NAWM) were correlated (Pearson correlation) and AUCs were calculated to assess diagnostic accuracy. Additionally, lesions were visually classified as hypointense, isointense, or hyperintense. We calculated accuracy at two thresholds: low threshold (between hypointense-isointense) and high threshold (between isointense-hyperintense). Results A total of 173 lesions, both enhancing and non-enhancing, measured in 115 patients (93 glioma, 16 metastasis, and 6 lymphoma) showed a very high correlation of 0.96 (95% CI: 0.88–0.99) between ASL-CBF ratios and ASL-PWI ratios. AUC was 0.76 (95%CI: 0.65–0.88) for ASL-CBF ratios and 0.72 (95%CI: 0.58–0.85) for ASL-PWI ratios. Diagnostic accuracy of visual assessment for enhancing lesions was 0.72. Conclusion ASL-PWI ratios and ASL-CBF ratios showed a high correlation and comparable AUCs; therefore, quantification of ASL-CBF could be omitted in these patients. Visual classification had comparable diagnostic accuracy to the ASL-PWI or ASL-CBF ratios. Clinical relevance statement This study shows that CBF quantification of ASL perfusion MRI could be omitted for brain tumour surveillance and that visual assessment provides the same diagnostic accuracy. This greatly reduces the complexity of the use of ASL in routine clinical practice. Key Points • Arterial spin labelling MRI for clinical brain tumour surveillance is undervalued and underinvestigated. • Non-quantitative and quantitative arterial spin labelling assessments show high correlation and comparable diagnostic accuracy. • Quantification of arterial spin labelling MRI could be omitted to improve daily clinical workflow.