Genotype Data and Derived Genetic Instruments of Adolescent Brain Cognitive Development Study® for Better Understanding of Human Brain Development

The data release of Adolescent Brain Cognitive Development ® (ABCD) Study represents an extensive resource for investigating factors relating to child development and mental wellbeing. The genotype data of ABCD has been used extensively in the context of genetic analysis, including genome-wide assoc...

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Bibliographic Details
Published inBehavior genetics Vol. 53; no. 3; pp. 159 - 168
Main Authors Fan, Chun Chieh, Loughnan, Robert, Wilson, Sylia, Hewitt, John K.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2023
Springer Nature B.V
Subjects
Adolescent
Adolescent Development
Behavioral Science and Psychology
Brain
Child
Child development
Clinical Psychology
Cognition
Cognitive ability
Cognitive development
Genetic analysis
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomics
Genotype
Genotype & phenotype
Genotypes
Health Psychology
Humans
Original Research
Psychology
Public Health
Relatedness
Subsets
Genetic
Data release
Adolescent Brain Cognitive Development Study
Genotyping
ABCD
Genomic
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Summary:The data release of Adolescent Brain Cognitive Development ® (ABCD) Study represents an extensive resource for investigating factors relating to child development and mental wellbeing. The genotype data of ABCD has been used extensively in the context of genetic analysis, including genome-wide association studies and polygenic score predictions. However, there are unique opportunities provided by ABCD genetic data that have not yet been fully tapped. The diverse genomic variability, the enriched relatedness among ABCD subsets, and the longitudinal design of the ABCD challenge researchers to perform novel analyses to gain deeper insight into human brain development. Genetic instruments derived from the ABCD genetic data, such as genetic principal components, can help to better control confounds beyond the context of genetic analyses. To facilitate the use genomic information in the ABCD for inference, we here detail the processing procedures, quality controls, general characteristics, and the corresponding resources in the ABCD genotype data of release 4.0.
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ISSN:0001-8244
1573-3297
1573-3297
DOI:10.1007/s10519-023-10143-0