Sentinel Lymph Node Mapping and Biopsy in Cats with Solid Malignancies: An Explorative Study

• Published in: Animals (Basel) Vol. 12; no. 22; p. 3116
• Main Authors: Chiti, Lavinia Elena, Gariboldi, Elisa Maria, Stefanello, Damiano, De Zani, Donatella, Grieco, Valeria, Nolff, Mirja Christine
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.11.2022; MDPI
• Subjects: Biopsy; cancer; cat; Cellular biology; Complications; Correspondence; Dissection; Feasibility; feline; Fluorescence; Histopathology; I.R. radiation; Lymph nodes; Lymphatic system; Lymphography; Malignancy; Mapping; Metastases; Metastasis; Morbidity; sentinel lymph node; Solid tumors; staging; Tumors; Italy; Switzerland; sentinel lymph node; cancer; feline; staging; cat
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani12223116

There is increasing evidence on the utility of sentinel lymph node (SLN) biopsy (SLNB) for the staging of dogs with various malignancies; however, comparable information is missing in cats. This multi-institutional study aims at reporting the feasibility and detection rate of SLNB guided by lymphoscintigraphy and the blue dye or near-infrared fluorescent lymphography (NIRF-L) in cats with solid tumors. In total, 12 cats presented with 14 solid malignancies that underwent curative-intent surgical excision of the primary tumor and SLNB were retrospectively enrolled. The mapping technique used, location and number of SLN, correspondence with the regional lymph node (RLN), and histological status of the SLN were retrieved. The detection rate and complications of SLNB were also recorded. NIRF-L was performed in 64.3% of tumors and lymphoscintigraphy in 35.7%. The detection rate was 100% for both techniques. The SLN did not correspond (fully or partially) to the RLN in 71.4% of cases, with multiple SLN being excised in 9/14 tumors. No complications related to SLNB were recorded. At histopathology, metastases were identified in 41.7% of cats, all with mast cell tumors (MCT). SLNB guided by NIRF-L or lymphoscintigraphy is feasible and safe in cats with solid tumors and should be suggested for correct tumor staging in cats, especially with MCT.