Bronchiolitis obliterans organizing pneumonia in patients with autoimmune rheumatic diseases

• Published in: Immunologic research Vol. 61; no. 1-2; pp. 97 - 103
• Main Authors: Rojas, Carmen Maria Lara, Borella, Elisabetta, Palma, Lavinia, Ragozzino, Silvio, De Ramón, Enrique, Gomez-Huelgas, Ricardo, Punzi, Leonardo, Doria, Andrea
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2015; Springer Nature B.V
• Subjects: Allergology; Autoimmune diseases; Autoimmune Diseases - complications; Autoimmune Diseases - diagnosis; Biomedical and Life Sciences; Biomedicine; Cryptogenic Organizing Pneumonia - complications; Cryptogenic Organizing Pneumonia - diagnosis; Cryptogenic Organizing Pneumonia - epidemiology; Cryptogenic Organizing Pneumonia - therapy; Cutting Edge in Autoimmunity; Humans; Immunology; Internal Medicine; Medicine/Public Health; Pneumonia; Rheumatic diseases; Rheumatic Diseases - complications; Rheumatic Diseases - diagnosis; Sjögren’s syndrome; Systemic lupus erythematosus; Autoimmune diseases; Polymyositis/dermatomyositis; Bronchiolitis obliterans organizing pneumonia; Systemic sclerosis
• ISSN: 0257-277X; 1559-0755
• DOI: 10.1007/s12026-014-8607-z

Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to corticosteroids and an excellent prognosis. It can occur in association with a broad spectrum of clinical conditions or can be isolated, in this last case named cryptogenic organizing pneumonia. We searched for BOOP in patients with autoimmune rheumatic diseases (ARD) in the literature, and we found 32 well-documented cases. We reported here demographic features, manifestations, treatment and outcome of patients with BOOP associated with ARD. Notably, BOOP can be the presenting feature in some patients with ARD; thus, a close follow-up of patients with BOOP is recommended.