Cost-effectiveness analysis of seasonal influenza vaccination during pregnancy: A systematic review

• Published in: Travel medicine and infectious disease Vol. 55; p. 102632
• Main Authors: Ostad-Ahmadi, Zakieh, Boccalini, Sara, Daemi, Amin, Mahboub-Ahari, Alireza
• Format: Journal Article
• Language: English
• Published: Philadelphia Elsevier Ltd 01.09.2023; Elsevier Limited; Elsevier
• Subjects: Clinical trials; Content analysis; Cost analysis; Decision trees; Disease control; Economic analysis; Economics; GDP; Gross Domestic Product; Hospitalization; Infectious diseases; Influenza; Intervention; Per capita; Pregnancy; Systematic review; Travel medicine; Vaccination; Vaccines; Women; Womens health; United States > US; Laos; Europe; Japan
• ISSN: 1477-8939; 1873-0442
• DOI: 10.1016/j.tmaid.2023.102632

Seasonal influenza vaccination is clinically important and reduces hospitalization costs for pregnant women. However, is it also a cost-effective intervention? We conducted a systematic search of Medline (via PUBMED), EMBASE, SCOPUS, and Web of Science databases. We included any economic evaluation studies that reported Incremental Cost-Effectiveness Ratios for vaccinating pregnant women against influenza. Out of 927 potentially eligible articles, only 14 full texts met our inclusion criteria. In almost all studies, vaccinating pregnant women was a cost-effective and cost-saving strategy. In one study, it was not cost-effective when the researchers used costs and probabilities related to other groups (healthy adults) due to the lack of data for pregnant women. The main factors influencing the cost-effectiveness of the studies were vaccine efficacy and vaccination cost. Influenza vaccination of pregnant women is a cost-effective intervention. More studies on the cost-effectiveness of this intervention in underdeveloped countries are needed. pregnancy, cost-effectiveness, cost-utility, cost-benefit, influenza vaccine, women, economic evaluation.