Biomarkers as MEDiators of racial disparities in risk factors (BioMedioR): Rationale, study design, and statistical considerations

Relative to White adults, Black adults have a substantially higher prevalence of hypertension and diabetes, both key risk factors for stroke, cardiovascular disease, cognitive impairment, and dementia. Blood biomarkers have shown promise in identifying contributors to racial disparities in many chro...

Full description

Saved in:
Bibliographic Details
Published inAnnals of epidemiology Vol. 66; pp. 13 - 19
Main Authors Long, D. Leann, Guo, Boyi, McClure, Leslie A., Jaeger, Byron C., Tison, Stephanie E., Howard, George, Judd, Suzanne E., Howard, Virginia J., Plante, Timothy B., Zakai, Neil A., Koh, Insu, Cheung, Katharine L., Cushman, Mary
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2022
Subjects
Adult
Biomarkers
Black or African American
Cohort Studies
Diabetes
Humans
Hypertension
Racial disparity
Risk Factors
Study design
White People
Study design
Hypertension
Biomarkers
Diabetes
Racial disparity
Online AccessGet full text

Cover

More Information
Summary:Relative to White adults, Black adults have a substantially higher prevalence of hypertension and diabetes, both key risk factors for stroke, cardiovascular disease, cognitive impairment, and dementia. Blood biomarkers have shown promise in identifying contributors to racial disparities in many chronic diseases. We outline the study design and related statistical considerations for a nested cohort study, the Biomarker Mediators of Racial Disparities in Risk Factors (BioMedioR) study, within the 30,239-person biracial REasons for Geographic And Racial Differences in Stroke (REGARDS) study (2003-present). Selected biomarkers will be assessed for contributions to racial disparities in risk factor development over median 9.4 years of follow-up, with initial focus on hypertension, and diabetes. Here we outline study design decisions and statistical considerations for the sampling of 4,400 BioMedioR participants. The population for biomarker assessment was selected using a random sample study design balanced across race and sex to provide the optimal opportunity to describe association of biomarkers with the development of hypertension and diabetes. Descriptive characteristics of the BioMedioR sample and analytic plans are provided for this nested cohort study. This nested biomarker study will examine pathways with the target to help explain racial differences in hypertension and diabetes incidence.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1047-2797
1873-2585
DOI:10.1016/j.annepidem.2021.10.010