Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy

• Published in: Nanomaterials (Basel, Switzerland) Vol. 8; no. 3; p. 170
• Main Authors: Mrówczyński, Radosław, Jędrzak, Artur, Szutkowski, Kosma, Grześkowiak, Bartosz F, Coy, Emerson, Markiewicz, Roksana, Jesionowski, Teofil, Jurga, Stefan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.03.2018; MDPI
• Subjects: Cancer; Cancer therapies; Computed tomography; Cyclodextrins; Doxorubicin; Electron microscopy; Fourier transforms; Hepatocytes; I.R. radiation; Infrared spectroscopy; Internalization; Liver; Liver cancer; magnetic nanoparticles; Magnetic resonance imaging; Microscopy; MRI; Nanomaterials; nanomedicine; Nanoparticles; Nanotechnology; Near infrared radiation; NMR; Nuclear magnetic resonance; Photoelectron spectroscopy; polydopamine; Spectroscopy; Spectrum analysis; Synergistic effect; theranostic; Therapy; Transmission electron microscopy; X ray photoelectron spectroscopy; β-Cyclodextrin; nanomedicine; polydopamine; magnetic nanoparticles; theranostic; MRI
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano8030170

Polydopamine (PDA)-coated magnetic nanoparticles functionalized with mono-6-thio-β-cyclodextrin (SH-βCD) were obtained and characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Nuclear and Magnetic Resonance Imaging (NMR and MRI), and doxorubicin (DOXO)-loading experiments. The liver cancer cellular internalization of DOXO-loaded nanoparticles was investigated by confocal imaging microscopy. Synthesized nanomaterials bearing a chemotherapeutic drug and a layer of polydopamine capable of absorbing near-infrared light show high performance in the combined chemo- and photothermal therapy (CT-PTT) of liver cancer due to the synergistic effect of both modalities as demonstrated in vitro. Moreover, our material exhibits improved ₂ contrast properties, which have been verified using Carr-Purcell-Meiboom-Gill pulse sequence and MRI Spin-Echo imaging of the nanoparticles dispersed in the agarose gel phantoms. Therefore, the presented results cast new light on the preparation of polydopamine-based magnetic theranostic nanomaterials, as well as on the proper methodology for investigation of magnetic nanoparticles in high field MRI experiments. The prepared material is a robust theranostic nanoasystem with great potential in nanomedicine.