Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine

• Published in: Neurological sciences Vol. 36; no. 4; pp. 535 - 540
• Main Authors: Wang, Fengzhi, He, Qiu, Ren, Zhanxiu, Li, Fuyong, Chen, Wei, Lin, Xiang, Zhang, Hemin, Tai, Guofeng
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.04.2015; Springer Nature B.V
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Child; Female; Humans; Intercellular Adhesion Molecule-1 - blood; Interleukin-6 - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Migraine; Migraine Disorders - blood; Migraine Disorders - classification; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Psychiatry; Statistics as Topic; Young Adult; Inflammatory; Cytokines; Migraine; IL-6; ICAM1
• ISSN: 1590-1874; 1590-3478; 1590-3478
• DOI: 10.1007/s10072-014-2010-3

To investigate the associations of serum levels of intercellular adhesion molecule-1 (ICAM1) and the pro-inflammatory cytokine interleukin-6 (IL-6) with migraine and migraine subtypes, and to study their correlation with each other in this condition. We used enzyme-linked immunosorbent assay to measure serum levels of ICAM1 and IL-6 in 103 migraine patients with and without aura, in both attack and pain-free periods, and in 100 healthy control subjects. Serum levels of ICAM1 and IL-6 were significantly higher in migraine patients during attacks than in controls ( p  < 0.05). Serum ICAM1 levels were significantly higher in migraine with aura (MA) than in migraine without aura (MO), ( p  < 0.05). Correlation analysis indicated a significant positive correlation between serum levels of ICAM1 and IL-6 ( p  < 0.05) in migraine patients during attacks. Our results indicate that ICAM1 and IL-6 are involved in the pathogenesis of migraine attacks, possibly via an interactive mechanism.